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18248

Sigma-Aldrich

Protein Disulfide Isomerase from bovine liver

≥150 U/mg protein (protein ca. 40%)

Sinónimos:

PDI

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About This Item

Número de CAS:
37318-49-3
Comisión internacional de enzimas:
5.3.4.1 (BRENDA, IUBMB)
MDL number:
MFCD00163364
UNSPSC Code:
12352204

form

powder
powder with small lumps

specific activity

≥150 U/mg protein (protein ca. 40%)

mol wt

107 kDa by gel filtration
 57 kDa by SDS-PAGE

shipped in

wet ice

Storage temp.

−20°C

InChI

1S/C7H5Cl2NO5S/c8-4-2-5(9)6(16(13,14)15-10)1-3(4)7(11)12/h1-2H,10H2,(H,11,12)

Inchi Key

DHUYKLYJBKXDBM-UHFFFAOYSA-N

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Physical properties

Protein Disulfide Isomerase (PDI) from bovine liver is a homodimer with a molecular weight of 107 kDa (gel filtration) and the molecular weight of the monomer has been reported at 57 kDA (SDS-PAGE). The enzyme is a glycoprotein with 12% total carbohydrate content, composed of 4.6% mannose, 2.5% galactose, 1.4% NANA, and 3.5% 2-acetamido-2-deoxyglucose.

Unit Definition

1 unit corresponds to the amount of enzyme, which, in a glutathione-dithiothreitol-system, causes a change of absorbance of 0.001 per minute at pH 4.0 and 25°C.

Other Notes

Enzyme that accelerates the exchange reaction between disulfide bridges in proteins

replaced by

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Certificados de análisis (COA)

Lot/Batch Number
456441/1
1349120

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Pryank Patel et al.
Journal of molecular biology, 425(5), 929-943 (2013-01-01)
Anterior gradient 2 (AGR2) is a normal endoplasmic reticulum protein that has two important abnormal functions, amphibian limb regeneration and human cancer metastasis promotion. These normal intracellular and abnormal extracellular roles can be attributed to the multidomain structure of AGR2.
Zegbeh Z Kpadeh et al.
Journal of bacteriology, 195(8), 1825-1833 (2013-02-26)
The extracytoplasmic assembly of the Dot/Icm type IVb secretion system (T4SS) of Legionella pneumophila is dependent on correct disulfide bond (DSB) formation catalyzed by a novel and essential disulfide bond oxidoreductase DsbA2 and not by DsbA1, a second nonessential DSB
Pamela A Wearsch et al.
Methods in molecular biology (Clifton, N.J.), 960, 67-79 (2013-01-19)
The stability of the MHC (major histocompatibility complex) class I peptide repertoire is optimized during assembly in the endoplasmic reticulum (ER) and depends on the collective function of components of the peptide-loading complex (PLC). The chaperone-like molecule tapasin is the
Florian Langer et al.
Blood, 121(12), 2324-2335 (2013-01-15)
Lymphocyte depletion with antithymocyte globulin (ATG) can be complicated by systemic coagulation activation. We found that ATG activated tissue factor procoagulant activity (TF PCA) on monocytic cells more potently than other stimuli that decrypt TF, including cell disruption, TF pathway
Franz-Xaver Kober et al.
The Journal of biological chemistry, 288(3), 2029-2039 (2012-11-30)
About one-third of all cellular proteins pass through the secretory pathway and hence undergo oxidative folding in the endoplasmic reticulum (ER). Protein-disulfide isomerase (PDI) and related members of the PDI family assist in the folding of substrates by catalyzing the
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