10171832001

Aldehyde Dehydrogenase

from yeast

• Sinónimos: Aldehyde dehydrogenase
• UNSPSC Code: 12352204
• Número CE: 1.2.1.5 (BRENDA, IUBMB)
• NACRES: NA.54
• Specific activity: ~20 units/mg protein (At 25 °C with acetaldehyde as the substrate.)
• Biological source: yeast

Propiedades

• biological source: yeast
• form: lyophilized
• specific activity: ~20 units/mg protein (At 25 °C with acetaldehyde as the substrate.)
• packaging: pkg of 250 U
• manufacturer/tradename: Roche
• optimum pH: 8.75
• relevant disease(s): cancer
• storage temp.: 2-8°C

Descripción

General description

Aldehyde dehydrogenase (ALDH) is a soluble enzyme and its activity depends on potassium ions and cysteine. The family of ALDH comprises of 19 genes in human. ALDH gene is expressed in the nucleus, cytosol, mitochondria and endoplasmic reticulum of the cell. ALDH is a component of nicotinamide adenine dinucleotide (NADH) and nicotinamide adenine dinucleotide phosphate (NADPH) recycling systems.

Application

Aldehyde Dehydrogenase has been used to evaluate fiber-optic biosensors for measurement of acetaldehyde (AcH) in liquid phase (AcH biosensor).

Biochem/physiol Actions

Aldehyde dehydrogenase (ALDH) regulates the non-P450 aldehyde reduction enzyme system. It protects the cell from the effects of toxic aldehydes. Mutations in this gene are associated with Sjogren Larsson syndrome, Larsson syndrome, type II hyperprolinemia and cancer. ALDH takes part in the oxidation of aldehydes to acids. ALDH-2 lowers cardiac ischemia, which arises due to myocardial infarction or post cardiac surgery.

Physical form

Enzyme is stabilized with potassium phosphate buffer, pH approximately 6.

Analysis Note

Contaminants: <0.01% “NADH oxidase”, ADH, and LDH each

Other Notes

For life science research only. Not for use in diagnostic procedures.

Información de seguridad

• Pictogramas: GHS07,GHS08
• Palabra de advertencia: Warning
• Códigos de peligro: H332,H373
• Indicaciones de precaución: P260 - P271 - P304 + P340 + P312 - P314 - P501
• Hazard Classifications: Acute Tox. 4 Inhalation - STOT RE 2
• Clase de almacenamiento: 11 - Combustible Solids
• ¿Qué está pasando?: WGK 2
• Punto de inflamación (°F): does not flash
• Punto de inflamación (°C): does not flash