MABE421

Anti-Lymphoid-specific helicase (SMARCA6) Antibody, clone 2G7.1

clone 2G7.1, from mouse

• Sinónimos: Lymphoid-specific helicase, Proliferation-associated SNF2-like protein, SWI/SNF2-related matrix-associated actin-dependent regulator of chromatin subfamily A member 6
• Código UNSPSC: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Propiedades

• origen biológico: mouse
• Nivel de calidad: 100
• forma del anticuerpo: purified antibody
• tipo de anticuerpo: primary antibodies
• clon: 2G7.1, monoclonal
• reactividad de especies: human
• técnicas: immunohistochemistry: suitable; western blot: suitable
• isotipo: IgG1κ
• Nº de acceso NCBI: NP_060533
• Nº de acceso UniProt: Q9NRZ9
• Condiciones de envío: wet ice
• modificación del objetivo postraduccional: unmodified
• Información sobre el gen: human ... HELLS(3070)

Descripción

Descripción general

A member of the SNF2 family of chromatin remodeling proteins, Lymphoid-specific helicase (HELLS, also known as Lsh) assumes various roles in normal development, survival, de novo or maintenance DNA methylation, gene silencing, and heterochromatin formation and organization. It is shown to serve as cancer progression marker in conjunction with CEP55 and FOXM1 for the detection of head and neck squamous cell carcinoma (HNSCC). It is also reported that expression of Lsh is crucial for meiotic progression in mouse spermatocytes. Lsh is shown to directly associate with the 5′ DMR of the Cdkn1c promoter, and thereby regulate its gene expression. Additionally, Lsh is reported as a regulator of repressive chromatin at retrotransposons, and is demonstrated to mediate the silencing of stem cell-specific genes such as Oct4.

Inmunógeno

GST-tagged recombinant protein corresponding to human Lymphoid-specific helicase (SMARCA6).

Aplicación

Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected Lymphoid-specific helicase (SMARCA6) in human placenta tissue.

Research Category
Epigenetics & Nuclear Function

Research Sub Category
Signaling Neuroscience

This Anti-Lymphoid-specific helicase (SMARCA6) Antibody, clone 2G7.1 is validated for use in western blotting & IHC for the detection of Lymphoid-specific helicase (SMARCA6).

Calidad

Evaluated by Western Blotting in human thymus tissue lysate.

Western Blotting Analysis: 1.0 µg/mL of this antibody detected Lymphoid-specific helicase (SMARCA6) in 10 µg of human thymus tissue lysate.

Descripción de destino

~97 kDa observed

Forma física

Format: Purified

Protein G Purified

Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Almacenamiento y estabilidad

Stable for 1 year at 2-8°C from date of receipt.

Otras notas

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Información de seguridad

• Código de clase de almacenamiento: 12 - Non Combustible Liquids
• Clase de riesgo para el agua (WGK): WGK 1
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable