MABC95

Anti-S1PR2/EDG5 Antibody, clone 6E8.1

clone 6E8.1, from mouse

• Sinónimos: Sphingosine 1-phosphate receptor 2, S1P receptor 2, S1P2, Endothelial differentiation G-protein coupled receptor 5, Sphingosine 1-phosphate receptor Edg-5, S1P receptor Edg-5
• UNSPSC Code: 12352203
• NACRES: NA.41
• eCl@ss: 32160702
• Conjugate: unconjugated
• Clone: 6E8.1, monoclonal
• Application: IHC, WB
• Citations: 2

Propiedades

• biological source: mouse
• Quality Level: 100
• conjugate: unconjugated
• antibody form: purified immunoglobulin
• antibody product type: primary antibodies
• clone: 6E8.1, monoclonal
• species reactivity: human
• technique(s): immunohistochemistry: suitable (paraffin), western blot: suitable
• isotype: IgMκ
• NCBI accession no.: NP_004221
• UniProt accession no.: O95136
• shipped in: wet ice
• target post-translational modification: unmodified
• Gene Information: human ... S1PR2(9294)

Descripción

General description

Sphingosine 1-phosphate receptor 2 (S1PR2), otherwise known as EDG5, is a ubiquitous G-protein coupled receptor for lysosphingolipid sphingosine 1-phosphate (S1P). It is coupled to Gi, G12/13, and Gq pathways to regulate a number of second messengers and effector molecules, including cAMP, PLC, MAPK, RhoA, and Rac. S1PR2 mediates the effects of S1P on cell motility and embryonic development, among other cellular processes.

~35 kDa observed

Immunogen

GST-tagged recombinant protein corresponding to the cytoplasmic domain of human S1PR2/EDG5.

Application

Anti-S1PR2/EDG5 Antibody, clone 6E8.1 detects level of S1PR2/EDG5 & has been published & validated for use in Western Blotting, IHC(P).

Immunohistochemistry Analysis: A representative lot detected S1PR2/EDG5 in human tonsil, liver, colorectal cancer tissues.

Biochem/physiol Actions

This antibody recognizes the cytoplasmic domain of S1PR2/EDG5.

Physical form

Format: Purified

Analysis Note

Evaluated by Western Blot in human liver tissue lysate.

Western Blot Analysis: 1 µg/mL of this antibody detected S1PR2/EDG5 in 10 mg of human liver tissue lysate.

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Información de seguridad

• wgk: WGK 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• Clase de almacenamiento: 12 - Non Combustible Liquids