MABC539

Anti-SFRP2 Antibody, clone 80.8.6, azide free

clone 80.8.6, from mouse

• Sinónimos: Secreted frizzled-related protein 2, FRP-2, sFRP-2, Secreted apoptosis-related protein 1, SARP-1
• UNSPSC Code: 12352203
• NACRES: NA.41
• eCl@ss: 32160702
• Conjugate: unconjugated
• Clone: 80.8.6, monoclonal
• Application: IHC, inhibition assay
• Citations: 3

Propiedades

• Quality Segment: 100
• biological source: mouse
• conjugate: unconjugated
• antibody form: purified antibody
• antibody product type: primary antibodies
• clone: 80.8.6, monoclonal
• species reactivity: human
• technique(s): immunohistochemistry: suitable, inhibition assay: suitable
• isotype: IgG2aκ
• NCBI accession no.: NP_003004
• UniProt accession no.: Q96HF1
• shipped in: wet ice
• target post-translational modification: unmodified
• Gene Information: human ... SFRP2(6423)

Descripción

General description

Secreted frizzled-related proteins (SFRPs) may play a critical role in carcinogenesis by inhibiting the Wnt/beta-catenin signaling pathway. Secreted frizzled-related protein 2 (SFRP2) may be useful to further investigate mammary tumorigenesis as its expression increases with tumor progression in canine mammary gland tumors. SFRP2 in mouse embryos has been found to cause severe shortening of the thoracic region. Studies have shown that this protein is the essential stem cell paracrine factor that is thought to regulate myocardial survival and repair damage in the aftermath of an ischemic injury.

33 kDa calculated

Immunogen

Epitope: NTR domain

Linear peptide corresponding to the NTR domain of human SFRP2.

Application

Anti-SFRP2 Antibody, clone 80.8.6, azide free is an antibody against SFRP2 for use in IHC & inhibition.

Inhibition Assay Analysis: Anti-SFRP2, clone 80.8.6 inhibits tube formation and cell migration in vitro on SVR angiosarcoma cells, inhibits angiosarcoma and breast cancer growth in vivo, and increases nuclear NFATc3 levels.

Physical form

Format: Purified

Analysis Note

Evaluated by Immunohistochemistry in human prostate and human breast cancer tissue.

Imunnohistochemistry Analysis: A 1:500 dilution of this antibody detected SFRP2 in human prostate and human breast cancer tissue.

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Información de seguridad

• Clase de almacenamiento: 12 - Non Combustible Liquids
• wgk: WGK 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable