AG938

Synuclein, α, recombinant human

• Sinónimos: α-Synuclein protein, Alpha Synuclein
• Código UNSPSC: 12352200
• eCl@ss: 32160405
• NACRES: NA.41

Propiedades

• origen biológico: human
• Nivel de calidad: 100
• Ensayo: >95% (gel scan and mass spectrometry)
• Formulario: solid
• caducidad: 12 mo.
• fabricante / nombre comercial: Chemicon^®
• solubilidad: water: slightly soluble
• idoneidad: suitable for molecular biology
• Nº de acceso NCBI: NM_000345.2; NM_007308.1
• Nº de acceso UniProt: P37840
• Información sobre el gen: human ... SNCA(6622)

Descripción

Descripción general

Research area: Neuroscience

α-Synuclein, a member of the synuclein family of proteins that localize to presynaptic terminals under physiological conditions. It is comprised of three primary regions: an amino terminus containing apolipoprotein lipid-binding motifs, which are anticipated to form amphiphilic helices. The central region, known as non-Aβ component (NAC) containing a hydrophobic domain that gives β-sheet potential, and the carboxyl terminus, characterized by a high negative charge and remains unstructured. Under physiological conditions, members of the synuclein family, including α-synuclein, are predominantly neuronal proteins.[1][2]

Aplicación

Synuclein, α, recombinant human has been used:

• for preparation of α-synuclein fibrils to access the SAR228810 antibody against the risk of amyloid-related imaging abnormalities (ARIA).[3]
• to study the formation of isoasparate protein damage responsible to trigger familial Parkionsonian phenotypes.[4]
• to study its interaction with iron and copper, in order to understand their role in proteinopathies.[5]

Acciones bioquímicas o fisiológicas

Synuclein, α is the principal component of Lewy bodies and a pathological hallmark of synucleinopathies, including Parkinson’s disease (PD), dementia with Lewy bodies (DLB), and multiple system atrophy (MSA). The deposition of αS aggregates is a defining characteristic of all these diseases.[6]

Forma física

Lyophilized from TBS. Resuspend in water at a concentration of 1 mg/mL.

Almacenamiento y estabilidad

Maintain lyophilized material at -20ºC for up to 12 months after date of receipt. After reconstitution maintain at -20ºC to -70ºC for up to 2 weeks in undiluted aliquots. Avoid freeze/thaw cycles to avoid aggregation.

Información legal

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Información de seguridad

• Código de clase de almacenamiento: 13 - Non Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 1
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable