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AB10418

Sigma-Aldrich

Anti-Puma BH3 domain Antibody

from rabbit

Sinónimos:

BCL2 binding component 3, Bcl-2 binding component 3, p53 up-regulated modulator of apoptosis

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

rabbit

Quality Level

100

antibody form

purified antibody

antibody product type

primary antibodies

clone

polyclonal

species reactivity

mouse

technique(s)

western blot: suitable

NCBI accession no.

NP_055232

UniProt accession no.

Q9BXH1

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

mouse ... Bbc3(170770)

General description

PUMA is one of the pro-apoptotic Bcl-2 family members including Bax and Noxa, which are also transcriptional targets of p53. The PUMA gene encodes two BH3 domain-containing proteins termed PUMA-a and PUMA-b. PUMA proteins bind Bcl-2, localize to the mitochondria, and induce cytochrome c release and apoptosis in response to p53. PUMA may be a direct mediator of p53-induced apoptosis

Specificity

Other species have not been tested.
The antibody reacts with the 21 kDa Puma BH3 domain protein.

Immunogen

This antibody was developed against a synthetic peptide selected from the C-terminal region of human Puma.

Application

Anti-Puma BH3 domain Antibody is an antibody against Puma BH3 domain for use in WB.

Quality

Western Blot Analysis: 1:250 dilution of this antibody detected Puma BH3 domain on mouse brain lysate.

Target description

21 kDa

Physical form

Format: Purified

Analysis Note

Control
Western Blot : Mouse brain lysate

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

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Storage Class

10 - Combustible liquids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Bhargab Kalita et al.
PloS one, 11(12), e0168525-e0168525 (2016-12-31)
Development of an effective radio protector to minimise radiation-inflicted damages have largely failed owing to inherent toxicity of most of the agents examined so far. This study is centred towards delivering protection to lethally irradiated mice by pre-administration of a

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