8.51011

MSNT

Novabiochem^®

• Sinónimos: MSNT, 1-(Mesitylene-2-sulfonyl)-3-nitro-1H-1,2,4-triazole
• Fórmula empírica (notación de Hill): C₁₁H₁₂N₄O₄S
• Número de CAS: 74257-00-4
• Peso molecular: 296.30
• MDL number: MFCD00009754
• UNSPSC Code: 12352005

Propiedades

• product line: Novabiochem^®
• assay: ≥95.0% (HPLC)
• form: powder
• reaction suitability: reaction type: Coupling Reactions
• manufacturer/tradename: Novabiochem^®
• storage temp.: 15-25°C
• InChI: 1S/C11H12N4O4S/c1-7-4-8(2)10(9(3)5-7)20(18,19)14-6-12-11(13-14)15(16)17/h4-6H,1-3H3
• InChI key: SFYDWLYPIXHPML-UHFFFAOYSA-N

Descripción

General description

This versatile reagent was originally used as a coupling reagent in phosphotriester oligonucleotide synthesis [1-3]. In recent years, it has been increasingly used for the esterification of Fmoc-amino acids onto solid phase synthesis supports [4-12]. It has proved particularly effective in difficult cases involving unreactive linkers [8, 9] or enantiomerization prone amino acids [7]. In an investigation [6] into ester formation, in which the alcohol or carboxylic acid component was immobilized on a solid support, MSNT was found to give the best results of all the reagents tested (DCC, DCC/HOBt, DCC/DMAP, Ph₃P/DEAD).

The product number for this product was previously 01-62-0021.

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Linkage

Replaces: 01-62-0021

Analysis Note

Colour (visual): white to slight yellow to beige
Appearance of substance (visual): powder
Identity (IR): passes test
Assay (HPLC, area%): ≥ 95.0 % (a/a)

Legal Information

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany