8.20128

Saccharin

for synthesis

• Sinónimos: Saccharin
• Fórmula empírica (notación de Hill): C₇H₅NO₃S
• Número CAS: 81-07-2
• Peso molecular: 183.18
• UNSPSC Code: 12352115
• EC Index Number: 201-321-0
• NACRES: NA.22
• MDL number: MFCD00005866
• Assay: ≥98.0% (acidimetric)
• Form: crystals

Propiedades

• Quality Segment: 200
• assay: ≥98.0% (acidimetric)
• form: crystals
• mp: 228-230 °C
• storage temp.: 2-30°C
• SMILES string: [S]1(=O)(=O)NC(=O)c2c1cccc2
• InChI: 1S/C7H5NO3S/c9-7-5-3-1-2-4-6(5)12(10,11)8-7/h1-4H,(H,8,9)
• InChI key: CVHZOJJKTDOEJC-UHFFFAOYSA-N

Descripción

Application

• Gabapentin-saccharin co-crystals with enhanced physicochemical properties and in vivo absorption formulated as oro-dispersible tablets.: This study presents the formulation of gabapentin-saccharin co-crystals, demonstrating improved solubility and absorption, beneficial for pharmaceutical applications (Soliman et al., 2020, doi: 10.1080/10837450.2019.1687521).


• Improving the solubility, dissolution, and bioavailability of Ibrutinib by preparing it in a coamorphous state with saccharin.: The research focuses on enhancing the bioavailability of Ibrutinib through coamorphous preparation with saccharin, which is significant for cancer treatment (Shi et al., 2019, doi: 10.1016/j.xphs.2019.04.031).

Analysis Note

Assay (acidimetric): ≥ 98.0 %
Melting range (lower value): ≥ 226 °C
Melting range (upper value): ≤ 230 °C
Identity (IR): passes test

Información de seguridad

• Clase de almacenamiento: 11 - Combustible Solids
• wgk: WGK 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable