658460

AG 879 - CAS 148741-30-4 - Calbiochem

A cell-permeable, reversible, and substrate competitive inhibitor of nerve growth factor (NGF)-dependent p140^c-trk tyrosine phosphorylation (EC₅₀ = 10 µM) as well as NGF-induced phospholipase C-γ1 phosphorylation.

• Sinónimos: AG 879 - CAS 148741-30-4 - Calbiochem, α-Cyano-(3,5-di- t-butyl-4-hydroxy)thiocinnamide
• Fórmula empírica (notación de Hill): C₁₈H₂₄N₂OS
• Número de CAS: 148741-30-4
• Peso molecular: 316.46
• MDL number: MFCD00236450
• UNSPSC Code: 12352200

Propiedades

• Quality Level: 100
• assay: ≥95% (HPLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; protect from light
• color: orange-yellow
• solubility: DMSO: 100 mg/mL; acetic acid: soluble; methanol: soluble
• shipped in: ambient
• storage temp.: −20°C
• InChI: 1S/C18H24N2OS/c1-17(2,3)13-8-11(7-12(10-19)16(20)22)9-14(15(13)21)18(4,5)6/h7-9,22H,20H2,1-6H3/b16-12+
• InChI key: LCUMYVYIHXYBIA-FOWTUZBSSA-N

Descripción

General description

A cell-permeable, reversible, and substrate competitive inhibitor of nerve growth factor (NGF)-dependent p140^c-trk tyrosine phosphorylation (EC₅₀ = 10 µM) as well as NGF-induced phospholipase C-γ1 phosphorylation. Also blocks NGF-induced neurite outgrowth in PC12 cells. Does not affect the tyrosine phosphorylation of epidermal growth factor receptor or platelet-derived growth factor receptor. Inhibits insulin secretion in a dose-dependent manner.

A cell-permeable, reversible, and substrate competitive inhibitor of nerve growth factor (NGF)-dependent pp140^c-trk tyrosine phosphorylation (EC₅₀ = 10 µM), as well as NGF-induced phospholipase C-γ1 phosphorylation. Also shown to inhibit HER2 (IC₅₀ = 1 µM). Does not affect the tyrosine phosphorylation of epidermal growth factor receptor or platelet-derived growth factor receptor. Also inhibits insulin secretion in a dose-dependent manner.

Biochem/physiol Actions

Cell permeable: yes

EC50 = 10 µM inhibiting nerve growth factor (NGF)-dependent p140c-trk tyrosine phosphorylation

Primary Target
(NGF)-dependent p140c-trk tyrosine phosphorylation

Product does not compete with ATP.

Reversible: yes

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.







From Catalog:

Solubility- removed acetic acid, MeOH

Other Notes

Konrad, R.J., et al. 1996. J. Biol. Chem. 271, 24179.
Levitzki, A. and Gazit, A. 1995. Science. 267, 1782.
Ohmichi, M., et al. 1993. Biochemistry32, 4650.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Storage Class: 10-13 - German Storage Class 10 to 13