559406

SB 328437

A highly potent and selective CC chemokine receptor-3 (CCR3) antagonist.

• Sinónimos: SB 328437, (S)-Methyl-2-naphthoylamino-3-(4-nitrophenyl)propionate
• Fórmula empírica (notación de Hill): C₂₁H₁₈N₂O₅
• Número de CAS: 247580-43-4
• Peso molecular: 378.38
• Número MDL: MFCD16618397
• Código UNSPSC: 12352200

Propiedades

• Nivel de calidad: 100
• Ensayo: ≥98% (HPLC)
• Formulario: solid
• fabricante / nombre comercial: Calbiochem^®
• condiciones de almacenamiento: OK to freeze; protect from light
• color: white
• solubilidad: DMSO: 100 mg/mL
• Condiciones de envío: ambient
• temp. de almacenamiento: −20°C
• InChI: 1S/C21H18N2O5/c1-28-21(25)19(13-14-9-11-16(12-10-14)23(26)27)22-20(24)18-8-4-6-15-5-2-3-7-17(15)18/h2-12,19H,13H2,1H3,(H,22,24)/t19-/m0/s1
• Clave InChI: VMFGCGRAIBLAFY-IBGZPJMESA-N

Descripción

Descripción general

A highly potent and selective CC chemokine receptor-3 (CCR3) antagonist that acts as a high affinity, competitive inhibitor of ¹²⁵I-eotaxin and ¹²⁵I-MCP-4 binding to human eosinophils. Inhibits eotaxin-, eotaxin-2-, and MCP-4-mediated human eosinophil chemotaxis (IC₅₀ = 32, 25, and 55 nM, respectively) and calcium mobilization in CCR3-transfected RBL-2H3 cells (IC₅₀ = 38, 35, and 20 nM, respectively).

Acciones bioquímicas o fisiológicas

Cell permeable: no

Primary Target
CC chemokine receptor-3 (CCR3)

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 38, 35, and 20 nM against calcium mobilization induced by eotaxin, eotaxin-2, or MCP-4, respectively

Envase

Packaged under inert gas

Advertencia

Toxicity: Standard Handling (A)

Reconstitución

Following reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 6 months at -20°C.

Otras notas

White, J.R., et al. 2000. J. Biol. Chem.275, 36626.

Información legal

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable