555556

Rho Kinase Inhibitor VII

The Rho Kinase Inhibitor VII controls the biological activity of Rho Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

• Sinónimos: Rho Kinase Inhibitor VII, ROCK Inhibitor VII, Rho Kinase Inhibitor VII
• Fórmula empírica (notación de Hill): C₂₁H₂₄N₈
• Peso molecular: 388.47
• UNSPSC Code: 12352200

Propiedades

• Quality Level: 100
• assay: ≥95% (HPLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; desiccated (hygroscopic); protect from light
• color: light beige
• solubility: DMSO: 1 mg/mL; water: 1 mg/mL
• shipped in: ambient
• storage temp.: −20°C

Descripción

General description

A cell-permeable triaminotriazine ROCK inhibitor (IC₅₀ = 6 nM in a cell-free ROCK1 kinase assay) that affects 24 other commonly studied non-ROCK kinases only at much higher concentrations (IC₅₀ >2 µM) and effectively blocks MCP-1-induced THP-1 cell migration (IC₅₀ = 30 nM) in vitro. Subcutaneous injection (3-10 mg/kg) of ROCK Inhibitor VII and oral dosing (30 mg/kg) of Y-27632 (Cat. Nos. 688000 & 688001) are both reported to significantly reduce arterial blood pressure in a spontaneous hypertensive rat model in vivo.

A cell-permeable triaminotriazine ROCK inhibitor (IC₅₀ = 6 nM in a cell-free ROCK1 kinase assay) that affects 24 other commonly studied non-ROCK kinases only at much higher concentrations (IC₅₀ >2 µM) and effectively blocks MCP-1-induced THP-1 cell migration (IC₅₀ = 30 nM) in vitro. Subcutaneous injection (3-10 mg/kg) of ROCK Inhibitor VII and oral dosing (30 mg/kg) of Y-27632 (Cat. Nos. 688000 & 688001) are both reported to significantly reduce arterial blood pressure in a spontaneous hypertensive rat model in vivo.

Packaging

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Other Notes

Ho, K.K., et al. 2009. Bioorg. Med. Chem. Lett.19, 6027.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable