Saltar al contenido
MilliporeSigma
Todas las fotos(1)

Documentos clave

528244

Millipore

Platensimycin, Streptomyces sp.

A cell-permeable Streptomyces-derived antibiotic that exhibits broad-spectrum Gram-positive antibacterial activity by selectively targeting the elongation condensing enzyme FabF.

Sinónimos:

Platensimycin, Streptomyces sp.

Iniciar sesiónpara Ver la Fijación de precios por contrato y de la organización

Seleccione un Tamaño

100 MG
EUR 414.20
250 MG
EUR 571.50
500 MG
EUR 871.80
1 G
EUR 1,105.80
2.5 G
EUR 2,123.70
5 G
EUR 3,120.80
10 G
EUR 4,605.40

Referencia (SKU) del distribuidor: EN300-1138981-100MG

EUR 414.20


Se envía en 14 días desde el socio de Aldrich

Solicitar un pedido a granel

Seleccione un Tamaño

Cambiar Vistas
100 MG
EUR 414.20
250 MG
EUR 571.50
500 MG
EUR 871.80
1 G
EUR 1,105.80
2.5 G
EUR 2,123.70
5 G
EUR 3,120.80
10 G
EUR 4,605.40

About This Item

Fórmula empírica (notación de Hill):
C24H27NO7
Número de CAS:
Peso molecular:
441.47
UNSPSC Code:
12352200

Referencia (SKU) del distribuidor: EN300-1138981-100MG

EUR 414.20


Se envía en 14 días desde el socio de Aldrich

Solicitar un pedido a granel

Quality Level

assay

≥93% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

tan

solubility

DMSO: 20 mg/mL
ethanol: 20 mg/mL

shipped in

wet ice

storage temp.

−20°C

InChI

1S/C24H27NO7/c1-22(7-6-17(28)25-18-14(26)4-3-13(19(18)29)21(30)31)16(27)5-8-24-10-12-9-15(20(22)24)32-23(12,2)11-24/h3-5,8,12,15,20,26,29H,6-7,9-11H2,1-2H3,(H,25,28)(H,30,31)/t12-,15+,20+,22-,23+,24+/m1/s1

General description

A cell-permeable Streptomyces-derived antibiotic that exhibits broad-spectrum Gram-positive antibacterial activity by selectively targeting the elongation condensing enzyme FabF (IC50 = 48 and 160 nM against S. aureus and E. coli FabF, respectively), but not the initiation condensing enzyme FabH (IC50 = 67 µM), involved in type II fatty acid synthesis (FASII). Binding studies indicate that acyl-FabF intermediate complex formation induces a FabF conformation change that is necessary for Platensimycin interaction. Platensimycin effectively kills numerous Staphylococcus aureus, Enterococcus faecium, and Streptococcus pneumoniae strains, including the ones that are resistant to methicillin and vancomycin (Cat. No. 627850). Platensimycin does not exhibit antifungal activity towards Candida albicans (no effect at 64 µg/ml) or toxicity toward mammalian HeLa culture (no effect at 1000 µg/ml) and is efficacious in treating S. aureus infection in mice in vivo (~105-fold bacteria titre reduction via a 24 h i.v. at 150 µg h-1). Although Platensimycin is ineffective toward wild-type E. coli due to the presence of functional multidrug efflux pump (no effect at 64 µg/ml), Platensimycin does inhibit the growth of efflux-negative E. coli strains.
A cell-permeable Streptomyces-derived antibiotic that exhibits broad-spectrum Gram-positive antibacterial activity by selectively targeting the elongation condensing enzyme FabF (IC50 = 48 and 160 nM against S. aureus and E. coli FabF, respectively), but not the initiation condensing enzyme FabH (IC50 = 67 µM), involved in type II fatty acid synthesis (FASII). Binding studies indicate that acyl-FabF intermediate complex formation induces a FabF conformation change that is necessary for Platensimycin interaction. Platensimycin effectively kills numerous Staphylococcus aureus, Enterococcus faecium, and Streptococcus pneumoniae strains, including the ones that are resistant to methicillin and vancomycin (Cat. No. 627850). Platensimycin does not exhibit antifungal activity towards Candida albicans (no effect at 64 µg/ml) or toxicity toward mammalian HeLa culture (no effect at 1000 µg/ml) and is efficacious in treating S. aureus infection in mice in vivo (~105-fold bacteria titre reduction via a 24 h i.v. at 150 µg h-1). Although Platensimycin is ineffective toward wild-type E. coli due to the presence of functional multidrug efflux pump (no effect at 64 µg/ml), Platensimycin does inhibit the growth of efflux-negative E. coli strains. Platensimycin has been shown to potently and selectively inhibit hepatocyte FAS and fatty acid oxidation (FAO), without affecting sterol synthesis. Platensimycin is also known as Fatty Acid Synthase Inhibitor III.

Warning

Toxicity: Harmful (C)

Other Notes

Wu, M., et al. 2011. Proc. Natl. Acad. Sci. USAin press.
Wang, J., et al. 2007. Proc. Natl. Acad. Sci. USA104, 7612.
Singh, S.B., et al. 2006. J. Am. Chem. Soc.128, 11916.
Wang, J., et al. 2006. Nature441, 358.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

¿Ya tiene este producto?

Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.

Visite la Librería de documentos

Nuestro equipo de científicos tiene experiencia en todas las áreas de investigación: Ciencias de la vida, Ciencia de los materiales, Síntesis química, Cromatografía, Analítica y muchas otras.

Póngase en contacto con el Servicio técnico