5.08159

Salvinorin A

• Sinónimos: Salvinorin A, κ-opioid Receptor Agonist, Salvinorin A, Divinorin A
• Fórmula empírica (notación de Hill): C₂₃H₂₈O₈
• Número de CAS: 83729-01-5
• Peso molecular: 432.46
• MDL number: MFCD05664742
• UNSPSC Code: 12352200
• NACRES: NA.77

Propiedades

• assay: ≥98% (HPLC)
• Quality Level: 100
• form: solid
• potency: 4.3 nM K_i
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; protect from light
• color: white
• solubility: ethanol: 10 mM; DMSO: 50 mM
• storage temp.: −70°C
• SMILES string: [o]1cc(cc1)[C@H]2OC(=O)[C@H]3[C@@]([C@@H]4[C@]([C@@H](C[C@@H](C4=O)OC(=O)C)C(=O)OC)(CC3)C)(C2)C
• InChI: 1S/C23H28O8/c1-12(24)30-16-9-15(20(26)28-4)22(2)7-5-14-21(27)31-17(13-6-8-29-11-13)10-23(14,3)19(22)18(16)25/h6,8,11,14-17,19H,5,7,9-10H2,1-4H3/t14-,15-,16-,17-,19-,22-,23-/m0/s1
• Inchi Key: OBSYBRPAKCASQB-AGQYDFLVSA-N

Descripción

General description

A highly potent and selective non-alkaloid positive allosteric modulator of Κ-opioid receptors (K_i = 4.3 nM and 16 nM for native and cloned κ-opioid receptors, respectively). Also acts as a D2DR partial agonist (K_i = 5-10 nM). Used in studies of addition.

Biochem/physiol Actions

Primary Target
k opioid receptor

Warning

Toxicity: Standard Handling (A)

Other Notes

Roth, B. et al., 2002. PNAS.99, 11934.
Valdés III., j., et al., 1984. J. Organic Chem.49, 4716.
Ortega, A., et al., 1982. J. of Chem. Society, Perkins Transactions I. 2505.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3