5.04479

JNJ 16259685 - CAS 409345-29-5 - Calbiochem

• Sinónimos: JNJ 16259685 - CAS 409345-29-5 - Calbiochem, (3,4-Dihydro-2H-pyrano[2,3-b]quinolin-7-yl)-(cis-4-methoxycyclohexyl)-methanone
• Fórmula empírica (notación de Hill): C₂₀H₂₃NO₃
• Número de CAS: 409345-29-5
• Peso molecular: 325.40
• Código UNSPSC: 12352200

Propiedades

• Ensayo: ≥98% (TLC)
• Nivel de calidad: 100
• Formulario: solid
• potencia: 0.55 nM IC₅₀; 0.34 nM K_i
• fabricante / nombre comercial: Calbiochem^®
• condiciones de almacenamiento: OK to freeze; protect from light
• color: white to off-white
• solubilidad: DMSO: 25 mM
• temp. de almacenamiento: 2-8°C

Descripción

Descripción general

An extremely potent, non-competitive antagonist for mGlu receptor subtype 1 (K_i = 0.34 nM; IC₅₀ = 0.55 nM). 400-fold more selective for mGlu₁ than for mGlu₅ and no interaction with mGlu₂, mGlu₃, mGlu₄, mGlu₆, AMPA or NMDA receptors (IC₅₀ >10 µM). Centrally active following systemic administration. Widely used for studying substance abuse, learning and memory, and neural plasticity.

Acciones bioquímicas o fisiológicas

Primary Target
mGlu₁

Advertencia

Toxicity: Standard Handling (A)

Reconstitución

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Otras notas

Lavreysen, H., et al. 2004. Neuropharmacology.47, 961.

Steckler, T., et al. 2005. Psychopharmacology.179, 198.

Steckler, T., et al. 2005. Behav. Brain. Res.164, 52.

Mabire, D., et al. 2005. J. Med. Chem.48, 2134.
Fukunaga, I., et al. 2007. Br. J. Pharmacol.151, 870.

Knopfel, T., et al. 2007. Br. J. Pharmacol.151, 723.

Achat-Mendes, C., et al. 2012. J. Pharmacol. Exp. Ther.343, 214.

Información legal

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany