487957

NOC-18

A nitric oxide (NO) donor similar to NOC-5, NOC-7 and NOC-12 but with an enhanced half-life.

• Sinónimos: NOC-18, DETA/NO, 2,2ʹ-(Hydroxynitrosohydrazino) bis-ethanamine, DETA NONOate, DETA/NO, 2,2ʹ-(Hydroxynitrosohydrazino)bis-ethanamine, DETA NONOate
• Fórmula empírica (notación de Hill): C₄H₁₃N₅O₂
• Número de CAS: 146724-94-9
• Peso molecular: 163.18
• UNSPSC Code: 12352200

Propiedades

• Quality Level: 100
• assay: ≥90% (HPLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; desiccated (hygroscopic); protect from light
• color: white
• solubility: PBS, pH 7.4: 100 mg/mL; 10 mM NaOH: soluble; water: soluble
• shipped in: ambient
• storage temp.: −20°C
• InChI: 1S/C4H13N5O2/c5-1-3-8(4-2-6)9(11)7-10/h11H,1-6H2/p+2
• InChI key: HMRRJTFDJAVRMR-UHFFFAOYSA-P

Descripción

General description

A nitric oxide (NO) donor similar to NOC-5 (Cat. No. 487950), NOC-7 (Cat. No. 487952) and NOC-12 (Cat. No. 487955) but with an enhanced half-life. Useful for the controlled release of NO in solution. Induces dose-dependent apoptosis in macrophages. Inhibits lipoprotein oxidation induced by Cu²⁺in vitro. Half-life (t_½) in PBS, pH 7.4 is 3400 minutes at 22°C. Relatively stable in alkaline solution (pH ≥10.0).

A nitric oxide (NO) donor similar to NOC-5 (Cat. No. 487950), NOC-7 (Cat. No. 487952), and NOC-12 (Cat. No. 487955) but with enhanced half-life for NO release (t_½ = 3400 min; PBS, pH 7.4, 22°C). Useful for the controlled release of NO in solution. Induces dose-dependent apoptosis in macrophages. Inhibits lipoprotein oxidation induced by Cu²⁺in vitro.

Biochem/physiol Actions

Cell permeable: no

Product does not compete with ATP.

Reversible: no

Warning

Toxicity: Irritant (B)

Reconstitution

Following reconstitution in NaOH, aliquot and freeze (-20°C). Stock solutions in NaOH are stable for up to 24 h at -20°C. Stock solutions in H₂O or PBS, pH 7.4 are unstable; reconstitute just prior to use.

Other Notes

Seccia, M., et al. 1996. Biochem. Biophys. Res. Commun. 220, 306.
Shibuta, S., et al. 1995. Neurosci. Lett. 187, 103.
Shimaoka, M., et al. 1995. Biochem. Biophys. Res. Commun. 209, 519.
Diodati, J.G., et al. 1993. J. Cardiovasc. Pharmacol. 22, 287.
Hrabie, J.A., et al. 1993. J. Org. Chem. 58,1472.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Storage Class: 10-13 - German Storage Class 10 to 13