441251

α₂-Macroglobulin, Human Plasma

A multifunctional, secreted glycoprotein that acts as a broad range irreversible protease inhibitor that forms a "trap" around most proteases.

• Sinónimos: α₂M, α₂MG
• Código UNSPSC: 12352202
• NACRES: NA.77

Propiedades

• Nivel de calidad: 100
• Ensayo: ≥95% (SDS-PAGE)
• Formulario: lyophilized
• fabricante / nombre comercial: Calbiochem^®
• condiciones de almacenamiento: OK to freeze
• solubilidad: aqueous buffer: soluble
• Condiciones de envío: ambient
• temp. de almacenamiento: −20°C

Descripción

Descripción general

A multifunctional, secreted glycoprotein that acts as a broad range irreversible protease inhibitor that forms a "trap" around most proteases. α₂M is so large a molecule that it tends to remain intravascular. Localized on the surface of peripheral blood lymphocytes. Multifunctional activities include promoting growth of mammalian cells in culture, stimulating regeneration of lymphocytes in irradiated mice, transporting zinc, and acting as proteinase inhibitor that controls the clotting and fibrinolytic system.

Acciones bioquímicas o fisiológicas

Cell permeable: no

Primary Target
broad range protease

Product does not compete with ATP.

Reversible: no

Advertencia

Toxicity: Standard Handling (A)

Forma física

Lyophilized from 30 mM sodium phosphate buffer, with glycine, pH 7.0.

Otras notas

Bonner, J.C., et al. 1995. J. Biol. Chem. 270, 16236.
Lysiak, J.J., et al. 1995. J. Biol. Chem.270, 21919.
Boisset, N., et al. 1992. J. Struct. Biol.108, 221.
Barrett, A.J. 1980. Methods Enzymol.80, 737.

Información legal

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Cláusula de descargo de responsabilidad

RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 1
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable