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437720

Lipoxin A₄

Name: Lipoxin A<SUB>4</SUB>
Brand: MM
Price: 463 USD

≥95% (HPLC), NK cell activity inhibitor, liquid

Oferta disponible

Sinónimos:

Lipoxin A₄, LXA₄, 5(S),6(R),15(S)-Trihydroxyeicosa-7- trans-9- trans-11- cis-13- trans-tetraenoic Acid, LXA₄, 5(S),6(R),15(S)-Trihydroxyeicosa-7-trans-9-trans-11-cis-13-trans-tetraenoic Acid

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Talla/SKU	Disponibilidad	Precio
25 μg	Comprobar disponibilidad del carrito	$463.00

Acerca de este artículo

Fórmula empírica (notación de Hill):

C₂₀H₃₂O₅

Número CAS:

89663-86-5

Peso molecular:

352.47

UNSPSC Code:

12352211

NACRES:

NA.77

MDL number:

MFCD00065845

Assay:

≥95% (HPLC)

Form:

liquid

Storage condition:

OK to freeze

$463.00

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Propiedades

Nombre del producto

Lipoxin A₄, Lipoxin A₄, CAS 89663-86-5, is a potent inhibitor of cytotoxic activity of human natural killer cells. Shown to be as potent as LTB4 in stimulating human neutrophils to generate superoxides.

Quality Segment

100

assay

≥95% (HPLC)

form

liquid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze

solubility

ethanol: soluble

shipped in

wet ice

storage temp.

−70°C

SMILES string

O[C@H]([C@H](O)\C=C\C=C\C=C/C=C/[C@@H](O)CCCCC)CCCC(=O)O

InChI

1S/C20H32O5/c1-2-3-8-12-17(21)13-9-6-4-5-7-10-14-18(22)19(23)15-11-16-20(24)25/h4-7,9-10,13-14,17-19,21-23H,2-3,8,11-12,15-16H2,1H3,(H,24,25)/b6-4-,7-5+,13-9+,14-10+/t17-,18+,19-/m0/s1

InChI key

IXAQOQZEOGMIQS-SSQFXEBMSA-N

Descripción

General description

Caution! Product contains volatile liquid. Keep product cold at all times.

Potent inhibitor of cytotoxic activity of human natural killer cells; shown to be as potent as LTB₄ in stimulating human neutrophils to generate superoxides. Involved in contractile responses and acts as a potent activator of human protein kinase C. Stimulates rapid lipid remodeling and pertussis-sensitive release of arachidonic acid in polymorphonuclear leukocytes. Stimulates MAP kinases via activation of G protein-coupled receptors.

Biochem/physiol Actions

Cell permeable: no

Primary Target
Potent inhibitor of cytotoxic activity of human natural killer cells

Product does not compete with ATP.

Reversible: no

Physical form

In Ethanol.

Preparation Note

Following initial thaw, aliquot and freeze (-70°C).

Other Notes

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

McMahon, B., et al. 2000. J. Biol. Chem. 275, 27566.
Soyombo, O., et al. 1994. Allergy 49, 230.
Flore, S., et al. 1992. J. Biol. Chem.267, 16168.
Badr, K.F., et al. 1989. Proc. Natl. Acad. Sci. USA86, 3438.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Flammable (J)

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Este artículo	L0521	437725	434625
Sigma-Aldrich 437720 Lipoxin A₄	Sigma-Aldrich L0521 Lipoxin A₄	Sigma-Aldrich 437725 Lipoxin A₄, 15-epi	Sigma-Aldrich 434625 Leukotriene B₄
description Lipoxin A₄, CAS 89663-86-5, is a potent inhibitor of cytotoxic activity of human natural killer cells. Shown to be as potent as LTB4 in stimulating human neutrophils to generate superoxides.	description ethanol solution	description Lipoxin A₄, 15-epi, CAS 171030-11-8, is an epimeric lipoxin A4 (Cat. No. 437720) analog that is more potent and metabolically stable than LXA4.	description Potent proinflammatory agent, primarily because of its actions on polymorphonuclear leukocytes that include chemotaxis, aggregation, degranulation, and stimulation of adherence to vascular endothelium.
form liquid	form ethanol solution	form liquid	form oil
assay ≥95% (HPLC)	assay -	assay ≥98% (HPLC)	assay ≥97% (HPLC)
Quality Level 100	Quality Level 200	Quality Level 100	Quality Level 100
manufacturer/tradename Calbiochem^®	manufacturer/tradename -	manufacturer/tradename Calbiochem^®	manufacturer/tradename Calbiochem^®
storage temp. −70°C	storage temp. −20°C	storage temp. −70°C	storage temp. −70°C
storage condition OK to freeze	storage condition -	storage condition OK to freeze, desiccated (hygroscopic), protect from light	storage condition OK to freeze