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Documentos clave

407952

Sigma-Aldrich

Ionomycin, Calcium Salt, Streptomyces conglobatus

Ionomycin, Calcium Salt, Streptomyces conglobatus, CAS 56092-82-1, is useful in cell activation experiments when calcium dose-response data are not required.

Sinónimos:

Ionomycin, Calcium Salt, Streptomyces conglobatus

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About This Item

Fórmula empírica (notación de Hill):
C41H70O9 · Ca
Número de CAS:
56092-82-1
Peso molecular:
747.07
Número MDL:
MFCD00083634
Código UNSPSC:
12352200

Nivel de calidad

100

Ensayo

≥97% (HPLC)

Formulario

solid

fabricante / nombre comercial

Calbiochem®

condiciones de almacenamiento

OK to freeze
protect from light

color

white to off-white

solubilidad

DMSO: 100 mg/mL

Condiciones de envío

ambient

temp. de almacenamiento

2-8°C

InChI

1S/C41H71O9.Ca/c1-25(21-29(5)34(43)24-35(44)30(6)22-27(3)20-26(2)14-15-38(46)47)12-11-13-28(4)39(48)31(7)36(45)23-33-16-18-41(10,49-33)37-17-19-40(9,50-37)32(8)42;/h11,13,24-33,36-37,39,42,45,48H,12,14-23H2,1-10H3,(H,46,47);/q-1;+2/p-1/b13-11+;/t25-,26-,27+,28-,29-,30+,31+,32-,33+,36+,37-,39-,40+,41+;/m1./s1

Clave InChI

RULWQOBWZOQCOY-SQNLDGQHSA-M

Descripción general

Highly specific for divalent cations (Ca2+ > Mg2+ >> Sr2+ = Ba2+) and more effective than antibiotic A23187 (Cat. No. 100105) as a mobile ion carrier for Ca2+. Complexes with Ca2+ between pH 7 and 9.5, with intense UV absorption. In contrast to A23187, it is not fluorescent. Useful for studies of Ca2+ transport across biological membranes. Induces apoptotic neuronal degeneration in embryonic cortical neurons. Also induces cell cycle arrest in the G1 interval of mature Burkitt lymphoma cell lines. Often used in cell activation experiments when calcium dose-response data is not required.
Useful in cell activation experiments when calcium dose-response data are not required. Also available as a 10 mM solution in DMSO (Cat. No. 407953).

Acciones bioquímicas o fisiológicas

Cell permeable: no
Primary Target
Useful in cell activation experiments
Product does not compete with ATP.
Reversible: no

Envase

Packaged under inert gas

Advertencia

Toxicity: Harmful (C)

Otras notas

Dupuy d′Angeac, A., et al. 1993. J. Cell Physiol.154, 44.
Lee, H.C. 1993. J. Biol. Chem.268, 293.

Información legal

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Pictogramas

Exclamation mark
GHS07

Palabra de señalización

Warning

Frases de peligro

H302

Clasificaciones de peligro

Acute Tox. 4 Oral

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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