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Documentos clave

407673

Sigma-Aldrich

Interleukin-8, Human, Recombinant, E. coli

Sinónimos:

rhIL-8

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About This Item

UNSPSC Code:
12352202

assay

≥97% (SDS-PAGE)

Quality Level

form

lyophilized

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze

impurities

≤100 EU/μg Endotoxin (EU/μg IL-8)

shipped in

ambient

storage temp.

−70°C

General description

Recombinant, human interleukin-8 expressed in E. coli. A potent proinflammatory cytokine produced by monocytes, fibroblasts, and keratinocytes in response to stimulation by LPS, IL-1, or TNF-α, and by T lymphocytes in response to PHA stimulation. Induces adhesion of neutrophils to endothelial cells. A physiological initiator of chemotactic migration of leukocytes. May be involved in chronic inflammation. IL-8 acts as an angiogenic factor in human gastric carcinoma.
Recombinant, human interleukin-8 expressed in E. coli. IL-8 is produced by monocytes, fibroblasts, and keratinocytes in response to stimulation by LPS, IL-1, or TNFα, and by T lymphocytes in response to PHA stimulation. Induces adhesion of neutrophils to endothelial cells. May be involved in chronic inflammation.

Biochem/physiol Actions

ED₅₀ = 150-300 ng/ml as measured by induction of myeloperoxidase release from human neutrophils

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-70°C) for long term storage or refrigerate (4°C) for short-term storage. Stock solutions are stable for up to 1 month at 4°C or up to 3 months at -70°C. Avoid freeze/thaw cycles of solutions.
Reconstitute to a concentration ≥10 µg/ml with sterile PBS containing at least 0.1% HSA or BSA.

Other Notes

Kido, S., et al. 2001. Eur. J. Cancer37, 1482.
Wilson, A.J., et al. 1999. Clin. Sci. 97, 385.
Harada, A., et al. 1994. J. Leukoc. Biol.56, 559.
Mazzucchelli, L., et al. 1994. Am. J. Pathol. 144, 997.
Oppenheim, J.J., et al. 1991. Annu. Rev. Immunol.9, 617.
Matsushima, K., et al. 1988. J. Exp. Med.167, 1883.
Schröeder, J., et al. 1987. J. Immunol.139, 3474.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable


Certificados de análisis (COA)

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