407673
Interleukin-8, Human, Recombinant, E. coli
Sinónimos:
rhIL-8
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About This Item
assay
≥97% (SDS-PAGE)
Quality Level
form
lyophilized
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
impurities
≤100 EU/μg Endotoxin (EU/μg IL-8)
shipped in
ambient
storage temp.
−70°C
General description
Recombinant, human interleukin-8 expressed in E. coli. A potent proinflammatory cytokine produced by monocytes, fibroblasts, and keratinocytes in response to stimulation by LPS, IL-1, or TNF-α, and by T lymphocytes in response to PHA stimulation. Induces adhesion of neutrophils to endothelial cells. A physiological initiator of chemotactic migration of leukocytes. May be involved in chronic inflammation. IL-8 acts as an angiogenic factor in human gastric carcinoma.
Recombinant, human interleukin-8 expressed in E. coli. IL-8 is produced by monocytes, fibroblasts, and keratinocytes in response to stimulation by LPS, IL-1, or TNFα, and by T lymphocytes in response to PHA stimulation. Induces adhesion of neutrophils to endothelial cells. May be involved in chronic inflammation.
Biochem/physiol Actions
ED₅₀ = 150-300 ng/ml as measured by induction of myeloperoxidase release from human neutrophils
Warning
Toxicity: Standard Handling (A)
Reconstitution
Following reconstitution, aliquot and freeze (-70°C) for long term storage or refrigerate (4°C) for short-term storage. Stock solutions are stable for up to 1 month at 4°C or up to 3 months at -70°C. Avoid freeze/thaw cycles of solutions.
Reconstitute to a concentration ≥10 µg/ml with sterile PBS containing at least 0.1% HSA or BSA.
Other Notes
Kido, S., et al. 2001. Eur. J. Cancer37, 1482.
Wilson, A.J., et al. 1999. Clin. Sci. 97, 385.
Harada, A., et al. 1994. J. Leukoc. Biol.56, 559.
Mazzucchelli, L., et al. 1994. Am. J. Pathol. 144, 997.
Oppenheim, J.J., et al. 1991. Annu. Rev. Immunol.9, 617.
Matsushima, K., et al. 1988. J. Exp. Med.167, 1883.
Schröeder, J., et al. 1987. J. Immunol.139, 3474.
Wilson, A.J., et al. 1999. Clin. Sci. 97, 385.
Harada, A., et al. 1994. J. Leukoc. Biol.56, 559.
Mazzucchelli, L., et al. 1994. Am. J. Pathol. 144, 997.
Oppenheim, J.J., et al. 1991. Annu. Rev. Immunol.9, 617.
Matsushima, K., et al. 1988. J. Exp. Med.167, 1883.
Schröeder, J., et al. 1987. J. Immunol.139, 3474.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class
11 - Combustible Solids
wgk_germany
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificados de análisis (COA)
Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»
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