401490

IKK-2 Inhibitor XI

The IKK-2 Inhibitor XI, also referenced under CAS 354810-80-3, controls the biological activity of IKK-2. This small molecule/inhibitor is primarily used for Inflammation/Immunology applications.

• Sinónimos: IKK-2 Inhibitor XI, (5-Phenyl-3-ureido)-thiophene-2-carboxamide
• Fórmula empírica (notación de Hill): C₁₂H₁₁N₃O₂S
• Número de CAS: 354810-80-3
• Peso molecular: 261.30
• UNSPSC Code: 12352200

Propiedades

• Quality Level: 100
• assay: ≥97% (HPLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; protect from light
• color: off-white
• solubility: DMSO: 10 mg/mL
• shipped in: ambient
• storage temp.: 2-8°C

Descripción

General description

A cell-permeable thiophenecarboxamide-ureido compound that acts as a potent, ATP-binding pocket-targeting inhibitor of IKK-2 (IC₅₀ = 25 nM), while affecting IKK-1 and JNK1 only at much higher concentrations (IC₅₀ = 1.0 and 1.6 µM, respectively). Shown to reduce LPS-induced TNF-α production in PBMCs (IC₅₀ = 250 nM) and exhibit oral availability with good pharmacokinetic in rats in vivo.

Packaging

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Other Notes

Baxter, A., et al. 2004. Bioorg. Med. Chem. Lett.14, 2817.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable