371545

Guanosine 5ʹ-O-(3-Thiotriphosphate), Tetralithium Salt - CAS 94825-44-2 - Calbiochem

G-protein-activating GTP analog, which is more resistant to hydrolysis than GTP.

• Sinónimos: Guanosine 5ʹ-O-(3-Thiotriphosphate), Tetralithium Salt - CAS 94825-44-2 - Calbiochem, GTPγ-S, 4Li
• Fórmula empírica (notación de Hill): C₁₀H₁₂N₅O₁₃P₃S · 4Li
• Número de CAS: 94825-44-2
• Peso molecular: 562.98
• MDL number: MFCD00135151
• UNSPSC Code: 12352200

Propiedades

• assay: ≥85% (HPLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; desiccated (hygroscopic)
• impurities: ≤12% GDP
• color: white
• solubility: water: 10 mg/mL
• shipped in: ambient
• storage temp.: −20°C

Descripción

General description

G-protein-activating GTP analog that is more resistant to hydrolysis than GTP. Has a direct stimulatory effect on Ins(1,4,5)P₃ formation in membranes.

G-protein-activating GTP analog, which is more resistant to hydrolysis than GTP. Induces exocytosis in isolated mouse pancreatic acinar cells. Also reported to stimulate insulin release from pancreatic β-cells.

Biochem/physiol Actions

Cell permeable: no

Primary Target
G-protein-activating GTP analog

Product does not compete with ATP.

Reversible: no

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions lose about 5% of their activity after 6 months at -20°C.

Other Notes

Iino, S., et al. 2000. FEBS Lett.479, 46.
Martelli, A.M., et al. 1996. Biochem. Biophys. Res. Commun. 218, 182.
Hess, S.D., et al. 1993. Science 259, 1169.
Ekstrom, R.C., et al. 1992. J. Biol. Chem.267, 22183.
McGuirk, S.M., and Dolphin, A.C. 1992. Neurosci.49, 117.
Vaca, L., et al. 1992. Eur. J. Physiol.422, 66.
Silk, S.T., et al. 1989. J. Biol. Chem.264, 21466.
Gilman, A.G. 1987. Annu. Rev. Biochem.56, 615.
Orellana, S., et al. 1987. J. Biol. Chem..262, 1638.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable