324897

eIF-2α Inhibitor, Salubrinal

InSolution, ≥95%

• Sinónimos: InSolution eIF-2α Inhibitor, Salubrinal, N-(2,2,2-Tichloro-1-(3-quinolin-8-ylthioureido)ethyl)cinnamamide
• Fórmula empírica (notación de Hill): C₂₁H₁₇Cl₃N₄OS
• Número de CAS: 304475-63-6
• Peso molecular: 479.81
• Número MDL: MFCD00548612
• Código UNSPSC: 12352200

Propiedades

• Nivel de calidad: 100
• Ensayo: ≥95% (HPLC)
• Formulario: liquid
• fabricante / nombre comercial: Calbiochem^®
• condiciones de almacenamiento: OK to freeze; avoid repeated freeze/thaw cycles; desiccated (hygroscopic); protect from light
• Condiciones de envío: dry ice
• temp. de almacenamiento: −70°C
• cadena SMILES: S=C(NC(NC(/C=C/C1=CC=CC=C1)=O)C(Cl)(Cl)Cl)NC2=CC=CC3=C2N=CC=C3

Descripción

Descripción general

A cell-permeable and selective inhibitor of the phosphatase complexes that dephosphorylate eukaryotic translation initiation factor 2 subunit α (eIF-2α). Shown to offer protection against ER stress-induced apoptosis (EC₅₀ ~15 µM in PC12 cells stimulated with 750 ng/ml of Tunicamycin (Cat. No. 654380). Prevents HSV replication both in Vero cells (IC₅₀ ~3 µM for reducing plaque formation) in vitro and in a mouse cornea infection model in vivo. The solid form of this compound (Cat. No. 324895) is also available.

Acciones bioquímicas o fisiológicas

Cell permeable: yes

Primary Target
eIF-2α

Envase

Packaged under inert gas

Advertencia

Toxicity: Irritant (B)

Forma física

A 50 mM (5 mg/208 µL) solution of eIF-2α Inhibitor, Salubrinal (Cat. No. 324895) in DMSO.

Reconstitución

Following initial thaw, aliquot and freeze (-70°C). Aliquots are stable for up to 6 months at -70°C.

Otras notas

Boyce, M., et al. 2005. Science307, 935.

Información legal

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Código de clase de almacenamiento: 10 - Combustible liquids
• Clase de riesgo para el agua (WGK): WGK 1
• Punto de inflamabilidad (°F): 188.6 °F - closed cup - (refers to pure substance)
• Punto de inflamabilidad (°C): 87 °C - closed cup - (refers to pure substance)