217720

Cdk1/5 Inhibitor

The Cdk1/5 Inhibitor, also referenced under CAS 40254-90-8, controls the biological activity of Cdk1/5. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

• Sinónimos: Cdk1/5 Inhibitor, 3-Amino-1H-pyrazolo[3,4-b]quinoxaline
• Fórmula empírica (notación de Hill): C₉H₇N₅
• Número de CAS: 40254-90-8
• Peso molecular: 185.19
• UNSPSC Code: 12352200

Propiedades

• Quality Level: 100
• assay: ≥95% (HPLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; protect from light
• color: red
• solubility: DMSO: 5 mg/mL
• shipped in: ambient
• storage temp.: 2-8°C
• InChI: 1S/C9H7N5/c10-8-7-9(14-13-8)12-6-4-2-1-3-5(6)11-7/h1-4H,(H3,10,12,13,14)
• InChI key: DWHVZCLBMTZRQM-UHFFFAOYSA-N

Descripción

General description

A 3-amino substituted pyrazoloquinoxaline compound that acts as a selective inhibitor of cyclin-dependent kinases 1 and 5 (Cdks; IC₅₀ = 0.6 µM and 0.4 µM for Cdk1/cyclin B and Cdk5/p25, respectively). Also shown to inhibit GSK-3β with (IC₅₀ = 1 µM). Does not inhibit Cdc25 phosphatase activity (IC₅₀ >10 µM).

A selective inhibitor of cyclin-dependent kinases 1 and 5 (Cdk1/Cdk5) (IC₅₀ = 600 nM for Cdk1/cyclin B and 400 nM for Cdk5/p25). Also shown to inhibit glycogen synthase kinase-3β (GSK-3β) (IC₅₀ = 1 µM). Does not inhibit Cdc25 phosphatase activity (IC₅₀ >10 µM).

Biochem/physiol Actions

Cell permeable: no

Primary Target
Cdk1/cyclin B, Cdk5/p25

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 0.6 µM and 0.4 µM for Cdk1/cyclin B and Cdk5/p25, respectively

Packaging

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Ortega, M.A., et al. 2002. Bioorg. Med. Chem.10, 2177.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 1