171264

AMPK Inhibitor, Compound C•2HCl

InSolution, ≥98%

• Sinónimos: InSolution AMPK Inhibitor, Compound C•2HCl, 6-(4-(2-Piperidin-1-yl-ethoxy)-phenyl)-3-pyridin-4-ylpyrazolo[1,5-a]pyrimidine, 2HCl, H₂O, Compound C, 2HCl, H₂O, AMPK Inhibitor I, AMPK Inhibitor I, 6-(4-(2-Piperidin-1-yl-ethoxy)-phenyl)-3-pyridin-4-ylpyrazolo[1,5-a]pyrimidine, 2HCl, H₂O, Compound C, 2HCl, H₂O
• Fórmula empírica (notación de Hill): C₂₄H₂₅N₅O
• Número de CAS: 866405-64-3
• Peso molecular: 399.49
• Número MDL: MFCD08705402
• Código UNSPSC: 12352200
• NACRES: NA.77

Propiedades

• Nivel de calidad: 100
• Ensayo: ≥98% (HPLC)
• Formulario: liquid
• fabricante / nombre comercial: Calbiochem^®
• condiciones de almacenamiento: OK to freeze; protect from light
• Condiciones de envío: ambient
• temp. de almacenamiento: −20°C
• cadena SMILES: [n]21ncc(c2ncc(c1)c4ccc(cc4)OCCN5CCCCC5)c3ccncc3
• InChI: 1S/C24H25N5O/c1-2-12-28(13-3-1)14-15-30-22-6-4-19(5-7-22)21-16-26-24-23(17-27-29(24)18-21)20-8-10-25-11-9-20/h4-11,16-18H,1-3,12-15H2
• Clave InChI: XHBVYDAKJHETMP-UHFFFAOYSA-N

Descripción

Descripción general

A cell-permeable pyrrazolopyrimidine compound that acts as a potent, selective, reversible, and ATP-competitive inhibitor of AMPK (AMP-activated protein kinase; K_i = 109 nM in the presence of 5 µM ATP and the absence of AMP). Does not affect the activities of ZAPK, Syk, PKCθ, PKA, or JAK3. Blocks celluar activities induced by AICAr (Cat. No.123040) or Metformin (Cat. No. 317240). Induces weight loss by attenuating AMPK-mediated food intake in mice. The solid form of this compound (Cat. No. 171260) is also available.

Envase

Packaged under inert gas

Forma física

A 10 mM (2 mg/408 µl) solution of AMPK Inhibitor, Compound C, 2HCl, (Cat. No. 171260) in H₂O.

Reconstitución

Following intial thaw, aliquot and freeze (-20°C).

Otras notas

Yu, P.B., et al. 2008. Nat. Chem. Biol4, 33.
Kim, E.K., et al. 2004. J. Biol. Chem.279, 19970.
Lee, M., et al. 2003. J. Biol. Chem.278, 39653.
Inoki, K., et al. 2003. Cell115, 577.
Fryer, L.G., 2002. FEBS Lett.531, 189.
Zhou, G., et al. 2001. J. Clin. Invest.108, 1167.

Información legal

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Código de clase de almacenamiento: 12 - Non Combustible Liquids
• Clase de riesgo para el agua (WGK): WGK 2
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable