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09-144

Sigma-Aldrich

Anti-phospho-Brk (Tyr342) Antibody

Upstate®, from rabbit

Sinónimos:

PTK6, protein tyrosine kinase 6, breast tumor kinase, protein-tyrosine kinase BRK

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

rabbit

Quality Level

100

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

purified by

affinity chromatography

species reactivity

human

manufacturer/tradename

Upstate®

technique(s)

western blot: suitable

isotype

IgG

NCBI accession no.

NM_005975.2

UniProt accession no.

Q13882

shipped in

wet ice

target post-translational modification

phosphorylation (pTyr342)

Gene Information

human ... PTK6(5753)

Specificity

Recognizes human phospho-Brk at tyrosine 342.

Immunogen

KLH conjugated synthetic peptide corresponding to amino acids encompassing Tyr342 of human Brk.

Application

Anti-phospho-Brk (Tyr342) Antibody is an antibody against phospho-Brk (Tyr342) for use in WB.
Research Category
Apoptosis & Cancer
Research Sub Category
Tumor Markers

Quality

Routinely evaluated by immunoblot.

Target description

~50 kDa

Physical form

ImmunoAffinity Purified
Purified rabbit polyclonal in buffer containing 0.1M Tris-Glycine (pH7.4, 150 mM NaCl) with 0.05% sodium azide.

Storage and Stability

Stable for 1 year at 2-8°C from date of receipt.

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

12 - Non Combustible Liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Priya S Mathur et al.
Molecular cancer research : MCR, 14(6), 563-573 (2016-03-18)
Disruption of the gene encoding Protein Tyrosine Kinase 6 (Ptk6) delayed differentiation and increased growth in the mouse intestine. However, Ptk6-null mice were also resistant to azoxymethane-induced colon tumorigenesis. To further explore functions of PTK6 in colon cancer, expression of
L Liu et al.
Oncogene, 25(35), 4904-4912 (2006-03-29)
Breast tumor kinase (Brk) is a non-receptor tyrosine kinase distantly related to the Src family kinase. It is expressed in more than 60% of breast tumors, but the biological role of this kinase remains to be determined. Only a limited
Chaoqun Liu et al.
Journal of experimental & clinical cancer research : CR, 40(1), 297-297 (2021-09-24)
Chemoresistance is the major cause of chemotherapy failure in patients with colorectal cancer (CRC). Protein tyrosine kinase 6 (PTK6) is aberrantly overexpressed in clinical CRC tissues undergoing chemotherapy. We studied if PTK6 contributed to the chemoresistance of CRC in human
Milica B Gilic et al.
Biochimica et biophysica acta. Reviews on cancer, 1874(2), 188432-188432 (2020-09-22)
Protein tyrosine kinase 6 (PTK6) is the most well studied member of the PTK6 family of intracellular tyrosine kinases. While it is expressed at highest levels in differentiated cells in the regenerating epithelial linings of the gastrointestinal tract and skin
Haoqun Qiu et al.
Oncogene, 24(36), 5656-5664 (2005-05-05)
Breast tumor kinase (Brk) is a member of the Frk family of nonreceptor tyrosine kinases that is overexpressed in a high percentage of human breast tumors. The downstream substrates and effectors of Brk remain largely unidentified. In this study, we
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