04-123
Anti-TAL-1 Antibody, clone BTL73
clone BTL73, Upstate®, from mouse
Sinónimos:
SCL, T-cell acute lymphocytic leukemia 1, TCL5, TAL-1, Stem cell protein
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100 μG
$456.00
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100 μG
$456.00
About This Item
Código UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41
origen biológico
mouse
Nivel de calidad
forma del anticuerpo
purified antibody
tipo de anticuerpo
primary antibodies
clon
BTL73, monoclonal
purificado por
affinity chromatography
reactividad de especies
human
fabricante / nombre comercial
Upstate®
técnicas
immunohistochemistry: suitable
western blot: suitable
isotipo
IgG1κ
Nº de acceso NCBI
Nº de acceso UniProt
Condiciones de envío
wet ice
Información sobre el gen
human ... TAL1(6886)
Descripción general
TAL-1, also known as SCL (stem cell leukemia), is a serine phosphoprotein and basic-helix-loop-helix transcription factor. TAL-1 is implicated in the genesis of hemopoietic malignancies and is a positive regulator of erythroid differentiation. A nonrandom, site-specific TAL-1 chromosomal translocation is commonly associated with oncogenic transformation in many T-cell acute lymphoblastic leukemias. TAL-1 binds to the LIM domain containing protein Rhombotin 2 (RBTN2), where it forms a complex with GATA1 or GATA 2 that is essential for erythropoiesis.
Especificidad
This antibody detects two predominant protein products of the SCL/TAL1 gene in T cell acute lymphoblastic leukemia (T-ALL): a full length PP42-TAL1 (42/44 kDa) and a truncated form PP24-TAL1 (24/26 kDa).
Inmunógeno
Epitope: C-Terminus
Recombinant GST-TAL1 (K Pulford, et al., 1995, Blood, 85: 675 - 684)
Aplicación
Research Category
Epigenetics & Nuclear Function
Epigenetics & Nuclear Function
Research Sub Category
Transcription Factors
Transcription Factors
Use Anti-TAL-1 Antibody, clone BTL73 (Mouse Monoclonal Antibody) validated in WB, IHC to detect TAL-1 also known as SCL, T-cell acute lymphocytic leukemia 1, TCL5, TAL-1, Stem cell protein.
Western Blot Analysis: 2 μg/mL of this lot detected a strong 44 kDa of PP42-TAL1 in Jurkat cell lysate, and also very faint PP24-TAL. Optimal working dilutions must be determined by the end user.
Calidad
Routinely evaluated by western blot on Jurkat cell lysate.
Descripción de destino
44 kDa
Forma física
Protein G Purified
Purified mouse monoclonal IgG1k in buffer containing PBS and 0.05% sodium azide.
Almacenamiento y estabilidad
Stable for 1 year at 2-8°C from date of receipt. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Nota de análisis
Control
Jurkat cell lysate
Jurkat cell lysate
Otras notas
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Información legal
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
Cláusula de descargo de responsabilidad
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Código de clase de almacenamiento
12 - Non Combustible Liquids
Clase de riesgo para el agua (WGK)
WGK 2
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
Certificados de análisis (COA)
Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»
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Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.
Suppression of super-enhancer-driven TAL1 expression by KLF4 in T-cell acute lymphoblastic leukemia.
Mina Noura et al.
Oncogene, 43(6), 447-456 (2023-12-16)
TAL1 is one of the most frequently dysregulated genes in T-ALL and is overexpressed in about 50% of T-ALL cases. One of the molecular mechanisms of TAL1 overexpression is abnormal mutations in the upstream region of the TAL1 promoter that
Riadh Lobbardi et al.
Cancer discovery, 7(11), 1336-1353 (2017-10-05)
T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive malignancy of thymocytes. Using a transgenic screen in zebrafish, thymocyte selection-associated high mobility group box protein (TOX) was uncovered as a collaborating oncogenic driver that accelerated T-ALL onset by expanding the initiating
A 3-bp deletion in the HBS1L-MYB intergenic region on chromosome 6q23 is associated with HbF expression.
Farrell, JJ; Sherva, RM; Chen, ZY; Luo, HY; Chu, BF; Ha, SY; Li, CK; Lee, AC; Li, RC; Li et al.
Blood null
Charlotte Smith et al.
Haematologica (2023-01-13)
T-cell acute lymphocytic leukemia protein 1 (TAL1) is one of the most frequently deregulated oncogenes in T-cell acute lymphoblastic leukemia (T-ALL). Its deregulation can occur through diverse in cis-alterations, including SIL-TAL1 microdeletions, translocations with Tcell Receptor (TCR) loci and, more
Mark A Gillespie et al.
Molecular cell, 78(5), 960-974 (2020-04-25)
Dynamic cellular processes such as differentiation are driven by changes in the abundances of transcription factors (TFs). However, despite years of studies, our knowledge about the protein copy number of TFs in the nucleus is limited. Here, by determining the
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