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04-002

Anti-SOCS1 Antibody, clone 4H1

clone 4H1, Upstate®, from mouse

Sinónimos:

suppressor of cytokine signaling 1, CIS1, CISH1, JAB, SOCS-1, SSI-1, SSI1, TIP3

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Tamaño de envaseSKUDisponibilidadPrecio
100 μg
Comprobar disponibilidad del carrito
$460.00

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UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
unconjugated
Clone:
4H1, monoclonal
Application:
IP, WB
Citations:
15

$460.00


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biological source

mouse

Quality Level

conjugate

unconjugated

antibody form

purified antibody

antibody product type

primary antibodies

clone

4H1, monoclonal

species reactivity

mouse, human

manufacturer/tradename

Upstate®

technique(s)

immunoprecipitation (IP): suitable, western blot: suitable

isotype

IgG1

NCBI accession no.

UniProt accession no.

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... SOCS1(8651)

General description

37 kDa

Immunogen

mouse SOCS1 recombinant GST fusion protein encompassing amino acids 2-78.

Application

Anti-SOCS1 Antibody, clone 4H1 is an antibody against SOCS1 for use in IP & WB.
Immunoblot Analysis: 1:1,000 dilution of this antibody detected SOCS1 in KG-1 cell lysate.
Immunoprecipitation (IP): 10 μg of this antibody immunoprecipitated SOCS1 from 200 μL of cell extract in RIPA buffer.
Research Category
Signaling
Research Sub Category
Immunological Signaling

Biochem/physiol Actions

Recognizes SOCS1

Physical form

Format: Purified
Protein G Purified

Preparation Note

2 years at 2° to 8°C from date of shipment.

Analysis Note

Routinely evaluated by immunoblot.

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Este artículo
04-004SAB5700844PRS3767
species reactivity

mouse, human

species reactivity

mouse, human

species reactivity

rat, mouse, human

species reactivity

human

clone

4H1, monoclonal

clone

1B2, monoclonal

clone

polyclonal

clone

polyclonal

antibody form

purified antibody

antibody form

purified immunoglobulin

antibody form

affinity isolated antibody

antibody form

affinity isolated antibody

biological source

mouse

biological source

mouse

biological source

rabbit

biological source

rabbit

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

technique(s)

immunoprecipitation (IP): suitable, western blot: suitable

technique(s)

western blot: suitable

technique(s)

immunohistochemistry: 1:50-1:200, western blot: 1:500-1:2000

technique(s)

indirect ELISA: suitable, western blot: suitable


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Clase de almacenamiento

12 - Non Combustible Liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable



Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Mariel E Eberle et al.
Journal of immunology (Baltimore, Md. : 1950), 188(11), 5644-5654 (2012-05-02)
Suppressor of cytokine signaling (SOCS) proteins serve as negative regulators of cytokine receptor signaling. However, SOCS proteins are not only induced via the JAK/STAT pathway, but are also transcribed on triggering of pattern recognition receptors such as TLRs. We now
Yun He et al.
The Journal of biological chemistry, 281(9), 5559-5566 (2006-01-13)
We have previously shown that ASK1 undergoes ubiquitination and degradation in resting endothelial cells (EC) and that proinflammatory cytokine tumor necrosis factor (TNF) induces deubiquitination and stabilization, leading to ASK1 activation. However, the mechanism for the regulation of ASK1 stability
Hong-Fei Xu et al.
Molecular medicine reports, 14(4), 3798-3804 (2016-09-08)
Intracerebral hemorrhage (ICH) results in inflammation, and glucocorticoids have been proven to be effective inhibitors of ICH‑induced inflammation. However, the precise underlying mechanisms of ICH‑induced inflammation and glucocorticoid function remain largely undefined. Using a mouse ICH model, the present study



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