S-023

Sirolimus-D₃ solution

100 μg/mL in acetonitrile, certified reference material, ampule of 1 mL

• Fórmula empírica (notación de Hill): C₅₁H₇₆D₃NO₁₃
• Número de CAS: 392711-19-2
• Peso molecular: 917.19
• UNSPSC Code: 41116107
• NACRES: NA.24

Propiedades

• grade: certified reference material
• Quality Level: 300
• feature: Snap-N-Spike^®/Snap-N-Shoot^®
• packaging: ampule of 1 mL
• manufacturer/tradename: Cerilliant^®
• concentration: 100 μg/mL in acetonitrile
• application(s): clinical testing
• format: single component solution
• shipped in: dry ice
• storage temp.: −70°C

Descripción

General description

A stable-labeled internal standard for the immunosuppressant sirolimus, an immunosuppressant and narrow therapeutic index drug used to prevent rejection in organ transplantation. This ertified calibration material is suitable for critical quantitative LC-MS/MS applications in clinical and diagnostic testing such as therapeutic drug monitoring assays to ensure patients remain within the drug′s narrow therapeutic range.

application

• Development of generic metabolic Raman calibration models: This study applied solution titration in aqueous phases and data augmentation techniques to develop robust Raman spectroscopy calibration models, potentially useful for in-line monitoring of bioprocesses including those involving Sirolimus-D₃ (Zhang et al., 2024).

Legal Information

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany

Snap-N-Shoot is a registered trademark of Cerilliant Corporation

Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• pictograms: GHS02,GHS07
• signalword: Danger
• hcodes: H225,H302 + H312 + H332,H319
• pcodes: P210 - P280 - P301 + P312 - P303 + P361 + P353 - P304 + P340 + P312 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Flam. Liq. 2
• Storage Class: 3 - Flammable liquids
• wgk_germany: WGK 2
• flash_point_f: 35.6 °F - closed cup
• flash_point_c: 2.0 °C - closed cup