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D-062

Supelco

21-Deoxycortisol solution

100 μg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

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About This Item

Fórmula empírica (notación de Hill):
C21H30O4
Número de CAS:
641-77-0
Peso molecular:
346.46
Número CE:
200-659-6
Número MDL:
MFCD00056476
Código UNSPSC:
41116107
ID de la sustancia en PubChem:
329798625
NACRES:
NA.24

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grado

certified reference material

Nivel de calidad

300

Formulario

liquid

Características

Snap-N-Spike®/Snap-N-Shoot®

envase

ampule of 1 mL

fabricante / nombre comercial

Cerilliant®

concentración

100 μg/mL in methanol

técnicas

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

aplicaciones

clinical testing
clinical testing

Formato

single component solution

temp. de almacenamiento

−20°C

cadena SMILES

CC(=O)C1(O)CCC2C3CCC4=CC(=O)CCC4(C)C3C(O)CC12C

InChI

1S/C21H30O4/c1-12(22)21(25)9-7-16-15-5-4-13-10-14(23)6-8-19(13,2)18(15)17(24)11-20(16,21)3/h10,15-18,24-25H,4-9,11H2,1-3H3/t15-,16-,17-,18+,19-,20-,21-/m0/s1

Clave InChI

LCZBQMKVFQNSJR-UJPCIWJBSA-N

Categorías relacionadas

Descripción general

A new calibration material suitable for LC/MS applications in clinical and diagnostic testing and endocrinology. 21-deoxycortisol, a steroid intermediate in the formation of cortisol, is measured in whole blood or serum by LC/MS for newborn screening of congenital adrenal hyperplasia (CAH) and other adrenal diseases.

Información legal

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

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Palabra de señalización

Danger

Clasificaciones de peligro

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

Órganos de actuación

Eyes

Código de clase de almacenamiento

3 - Flammable liquids

Clase de riesgo para el agua (WGK)

WGK 1

Punto de inflamabilidad (°F)

49.5 °F - closed cup

Punto de inflamabilidad (°C)

9.7 °C - closed cup

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J Fiet et al.
Annals of clinical biochemistry, 31 ( Pt 1), 56-64 (1994-01-01)
21-deoxycortisol (21-DF) is a steroid of strictly adrenal origin formed by the 11-hydroxylation of 17-hydroxyprogesterone. This metabolic pathway is minor in normal subjects, in whom basal plasma concentrations range from 0.03 to 0.63 nmol/L and from 0.865 to 1.50 nmol/L
Surface-activated chemical ionization ion trap mass spectrometry in the analysis of 21-deoxycortisol in blood.
Simone Cristoni et al.
Rapid communications in mass spectrometry : RCM, 18(12), 1392-1396 (2004-06-03)
M Hill et al.
Steroids, 60(9), 615-620 (1995-09-01)
A radioimmunoassay of three deoxycorticoids, namely 11 beta,17 alpha-dihydroxy-4-pregnene-3,20-dione (21-deoxycortisol), 17 alpha,21-dihydroxy-4-pregnene-3,20-dione (11-deoxycortisol), and 21-hydroxy-4-pregnene-3,20-dione (11-deoxycorticosterone) which are important for differential diagnosis of congenital adrenal disorders, is described and evaluated. Antisera against 3-(O-carboxymethyl)oximes conjugated to bovine serum albumin were raised
Vânia Tonetto-Fernandes et al.
Journal of pediatric endocrinology & metabolism : JPEM, 21(5), 487-494 (2008-07-29)
21-Hydroxylase deficiency (21OHD) is the commonest form of congenital adrenal hyperplasia, while 11betaOHD represents 5% of cases. Although both result from mutations in distinct genes, cases of 'apparent' combined 21OHD and 11betaOHD (AC21,11OHD) have been occasionally reported. A 6 year-old
K Müssig et al.
Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association, 114(4), 208-214 (2006-05-18)
Congenital adrenal hyperplasia results from 21-hydroxylase deficiency in more than ninety percent of cases. The classical form of 21-hydroxylase deficiency presents in the neonatal period with virilization or adrenal insufficiency, with or without concurrent salt wasting. We report on a
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