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MilliporeSigma

890860C

Avanti

14:0 TAP

Avanti Research - A Croda Brand 890860C

Sinónimos:

1,2-dimyristoyl-3-trimethylammonium-propane (chloride salt)

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About This Item

Fórmula empírica (notación de Hill):
C34H68NO4Cl
Número de CAS:
Peso molecular:
590.36
UNSPSC Code:
12352211
NACRES:
NA.25

form

liquid

packaging

pkg of 1 × 2.5 mL (890860C-25mg)
pkg of 2 × 4 mL (890860C-200mg)

manufacturer/tradename

Avanti Research - A Croda Brand 890860C

concentration

10 mg/mL (890860C-25mg)
25 mg/mL (890860C-200mg)

lipid type

cationic lipids
transfection

shipped in

dry ice

storage temp.

−20°C

SMILES string

[H]C(C[N+](C)(C)C)(OC(CCCCCCCCCCCCC)=O)COC(CCCCCCCCCCCCC)=O.[Cl-]

Categorías relacionadas

General description

1,2-dimyristoyl-3-trimethylammonium-propane (14:0 TAP) is a saturated cationic lipid with a positively charged headgroup. It has an alkyl chain length with 14 carbon atoms.

Application

1,2-dimyristoyl-3-trimethylammonium-propane (14:0 TAP) is suitable for:
  • preparation of cationic liposomes
  • reconstitution of bacteriorhodopsin (BR) and proteorhodopsin (PR) into liposomes
  • composing lipid–styrene maleic acid (SMA) complexes
  • liposome preparation by double emulsion method

Biochem/physiol Actions

1,2-dimyristoyl-3-trimethylammonium-propane (14:0 TAP) is useful for bicelle formation. Bicelles can be integrated into standard crystallization protocols, and in contrast to micelles, bicelles maintain the protein in a more native bilayer environment allowing proteins to be captured in a more biologically relevant orientation.

Packaging

5 mL Clear Glass Sealed Ampule (890860C-200mg)
5 mL Clear Glass Sealed Ampule (890860C-25mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

pictograms

Skull and crossbonesHealth hazard

signalword

Danger

Hazard Classifications

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 Oral - STOT SE 3

target_organs

Liver,Kidney, Respiratory system

Storage Class

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

wgk_germany

WGK 3

flash_point_f

does not flash

flash_point_c

does not flash


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Masafumi Tanaka et al.
Biochimica et biophysica acta. Biomembranes, 1862(5), 183209-183209 (2020-02-01)
Styrene maleic acid copolymers (SMA) form discoidal lipid nanoparticles (lipid nanodisks) that mimic plasma high-density lipoproteins. We have previously prepared and characterized lipid nanodisks composed of SMA and the neutral phospholipid 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC). In the present study, we tested whether
Reverse osmosis membranes based on a supported lipid bilayer with gramicidin A water channels
Saeki D, et al.
Desalination, 375, 48-53 (2015)
Lipid-induced dynamics of photoreceptors monitored by time-resolved step-scan FTIR spectroscopy
Jawurek M, et al.
Chemical Physics, 512, 53-61 (2018)
A E Regelin et al.
Biochimica et biophysica acta, 1464(1), 151-164 (2000-03-08)
In order to investigate the relationship between lipid structure and liposome-mediated gene transfer, we have studied biophysical parameters and transfection properties of monocationic DOTAP analogs, systematically modified in their non-polar hydrocarbon chains. Stability, size and (by means of anisotropy profiles)
Nishu Kanwa et al.
Physical chemistry chemical physics : PCCP, 22(6), 3234-3244 (2020-01-30)
In the present contribution, we investigate the interactions of lipid bilayer membranes of different charges and different phase states with aliphatic amino acids of varying charge (aspartic acid, glutamic acid, arginine and lysine) and hydrophobicity (serine, leucine and valine) by

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