890700C

12:0 EPC (Cl Salt)

Avanti Research^™ - A Croda Brand 890700C

• Sinónimos: 1,2-dilauroyl-sn-glycero-3-ethylphosphocholine (chloride salt)
• Fórmula empírica (notación de Hill): C₃₄H₆₉NO₈PCl
• Número de CAS: 474945-22-7
• Peso molecular: 686.34
• Código UNSPSC: 12352211
• NACRES: NA.25

Propiedades

• Formulario: liquid
• envase: pkg of 1 × 1 mL (890700C-10mg)
• fabricante / nombre comercial: Avanti Research^™ - A Croda Brand 890700C
• concentración: 10 mg/mL (890700C-10mg)
• tipo de lípido: cationic lipids; transfection
• Condiciones de envío: dry ice
• temp. de almacenamiento: −20°C
• cadena SMILES: O=P(OCC[N+](C)(C)C)(OC[C@]([H])(OC(CCCCCCCCCCC)=O)COC(CCCCCCCCCCC)=O)OCC.[Cl-]

Descripción

Descripción general

1,2-dilauroyl-sn-glycero-3-ethylphosphocholine (12:0 EPC) is a cationic phospholipid. 12:0 EPC is a short chain analog of dioleoyl ethylphosphatidylcholine. O-alkyl phosphatidylcholines constitute the first chemically stable triesters of biological lipid structures and the first cationic derivatives of phospholipids consisting entirely of biological metabolites linked with ester bonds. The lipid has low toxicity and is biodegradable.

Aplicación

1,2-dilauroyl-sn-glycero-3-ethylphosphocholine (12:0 EPC (Cl Salt)) is suitable:

• for use in lipoplex
• to study its effect on transfection of human umbilical artery endothelial cells (HUAEC)
• in liposome preparation
• in lipid mixtures to study its cubic phases of formation, stability and phase transitions

Acciones bioquímicas o fisiológicas

Chemically synthesized cationic lipids are applicable as non-viral gene carriers. Variation in the hydrocarbon chain of phosphatidylcholine (PC) derivatives affects transfection efficiency. 1,2-dilauroyl-sn-glycero-3-ethylphosphocholine (12:0 EPC) is preferred for transfection of cultured primary endothelial cells. 12:0 EPC forms lamellar lipoplexes possessing high to superior transfection activity.

Envase

5 mL Clear Glass Sealed Ampule (890700C-10mg)

Información legal

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Información de seguridad

• Pictogramas: GHS06,GHS08
• Palabra de señalización: Danger
• Frases de peligro: H302,H315,H319,H331,H336,H351,H361d,H372
• Consejos de prudencia: P201 - P260 - P264 - P280 - P304 + P340 + P311 - P403 + P233
• Clasificaciones de peligro: Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3
• Órganos de actuación: Central nervous system
• Código de clase de almacenamiento: 6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): does not flash
• Punto de inflamabilidad (°C): does not flash