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880680P

Avanti

C16 PEG750 Ceramide

Avanti Research™ - A Croda Brand 880680P, powder

Sinónimos:

N-palmitoyl-sphingosine-1-{succinyl[methoxy(polyethylene glycol)750]}

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About This Item

Número de CAS:
212116-78-4
Código UNSPSC:
12352211
NACRES:
NA.25

Formulario

powder

envase

pkg of 1 × 25 mg (880680P-25mg)

fabricante / nombre comercial

Avanti Research™ - A Croda Brand 880680P

Condiciones de envío

dry ice

temp. de almacenamiento

−20°C

cadena SMILES

O=C(CCC(OC[C@]([H])(NC(CCCCCCCCCCCCCCC)=O)[C@]([H])(O)/C=C/CCCCCCCCCCCCC)=O)OOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOC.C=C

Clave InChI

PZQTVIDFPGJTMH-TWVCMLEGSA-N

Descripción general

Ceramide is a sphingolipid metabolite. The ceramides differ in their acyl chain length.[1]

Aplicación

C16 PEG750 Ceramide might be used as a control to test for nonspecific interactions during titrations of DNA-nanotube complexes with polyethylene glycol (PEG)-conjugated lipids.[2]

Acciones bioquímicas o fisiológicas

Therapeutic drugs enclosed in poly-ethylene glycol (PEG) conjugated ceramide serves as liposomal carriers, ensuring a longer circulation period. It exhibits a neutral surface electrostatic charge which prevents the leaking of positively charged encapsulated drug molecule.[3]

Envase

5 mL Amber Glass Screw Cap Vial (880680P-25mg)

Información legal

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

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Certificados de análisis (COA)

Lot/Batch Number

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Prakrit V Jena et al.
ACS nano, 11(11), 10689-10703 (2017-09-13)
Lipid accumulation within the lumen of endolysosomal vesicles is observed in various pathologies including atherosclerosis, liver disease, neurological disorders, lysosomal storage disorders, and cancer. Current methods cannot measure lipid flux specifically within the lysosomal lumen of live cells. We developed
M S Webb et al.
Biochimica et biophysica acta, 1372(2), 272-282 (1998-07-24)
Poly(ethylene glycol) (PEG) conjugated lipids have been used to increase the circulation longevity of liposomal carriers encapsulating therapeutic compounds. PEG is typically conjugated to distearoylphosphatidylethanolamine (DSPE) via a carbamate linkage that results in a net negative charge on the phosphate
Michal Levy et al.
IUBMB life, 62(5), 347-356 (2010-03-12)
In mammals, ceramide, a key intermediate in sphingolipid metabolism and an important signaling molecule, is synthesized by a family of six ceramide synthases (CerS), each of which synthesizes ceramides with distinct acyl chain lengths. There are a number of common
Jamie L Betker et al.
Journal of pharmaceutical sciences (2020-02-01)
Nanoparticle-mediated drug delivery has long utilized PEGylation as a mechanism for reducing uptake by the reticuloendothelial system and extending circulation lifetimes. However, studies over the past 2 decades have established that immune responses to PEG can promote clearance on repeat injection

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