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880230C

Avanti

18:1 PEG5000 PE

Avanti Research™ - A Croda Brand 880230C

Sinónimos:

1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-5000] (ammonium salt)

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About This Item

Número de CAS:
474922-90-2
UNSPSC Code:
12352211
NACRES:
NA.25

form

liquid

packaging

pkg of 1 × 2.5 mL (880230C-25mg)
pkg of 2 × 4 mL (880230C-200mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand 880230C

concentration

10 mg/mL (880230C-25mg)
25 mg/mL (880230C-200mg)

shipped in

dry ice

storage temp.

−20°C

SMILES string

[H][C@@](COP([O-])(OCCNC([(OCH2CH2)113OCH3])=O)=O)(OC(CCCCCCC/C=C\CCCCCCCC)=O)COC(CCCCCCC/C=C\CCCCCCCC)=O.[NH4+]

Categorías relacionadas

Application

18:1 PEG5000 PE or 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-5000 has been used in small unilamellar vesicles (SUV).

Biochem/physiol Actions

18:1 PEG5000 PE, also known as 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-5000], is used along with lipid modified dendrimer copolymer to co-deliver siRNA and drugs to tumors.

Packaging

5 mL Clear Glass Sealed Ampule (880230C-200mg)
5 mL Clear Glass Sealed Ampule (880230C-25mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

signalword

Danger

Hazard Classifications

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 Oral - STOT SE 3

target_organs

Liver,Kidney, Respiratory system

Storage Class

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

wgk_germany

WGK 3

flash_point_f

does not flash

flash_point_c

does not flash

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Reconstitution of TCR signaling using supported lipid bilayers
Su X, et al.
Methods in Molecular Biology (2017)
Xiaolei Su et al.
Methods in molecular biology (Clifton, N.J.), 1584, 65-76 (2017-03-04)
Biochemical reconstitution has served as an important tool for understanding the mechanisms of many cellular processes including DNA replication, transcription, translation, vesicle trafficking, and ubiquitin-mediated proteolysis. Here, we demonstrate that biochemical reconstitution can be applied to studying a complex signaling
TCR--pMHC bond conformation controls TCR ligand discrimination
Sasmal DK, et al.
Cellular & Molecular Immunology, 65-76 (2017)
Dibyendu K Sasmal et al.
Cellular & molecular immunology, 17(3), 203-217 (2019-09-19)
A major unanswered question is how a TCR discriminates between foreign and self-peptides presented on the APC surface. Here, we used in situ fluorescence resonance energy transfer (FRET) to measure the distances of single TCR-pMHC bonds and the conformations of
Jiayi Pan et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 136, 18-28 (2019-01-12)
Multidrug resistance (MDR) significantly decreases the therapeutic efficiency of anti-cancer drugs. Its reversal could serve as a potential method to restore the chemotherapeutic efficiency. Downregulation of MDR-related proteins with a small interfering RNA (siRNA) is a promising way to reverse
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