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870865P

Avanti

BMP22

Avanti Research™ - A Croda Brand, powder

Sinónimos:

4-pentadecylbenzylphosphonic acid

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About This Item

Fórmula empírica (notación de Hill):
C22H39O3P
Número de CAS:
1306684-90-1
Peso molecular:
382.52
UNSPSC Code:
12352211
NACRES:
NA.25

assay

99% (TLC)

form

powder

packaging

pkg of 1 × 1 mg (870865P-1mg)
pkg of 1 × 5 mg (870865P-5mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand

lipid type

bioactive lipids

shipped in

dry ice

storage temp.

−20°C

SMILES string

CCCCCCCCCCCCCCCC1=CC=C(CP(O)(O)=O)C=C1

General description

BMP (bis(monoacylglycerol)phosphate) is synthesized from phosphatidylglycerol (PG) in alveolar macrophages. BMP is a unique phospholipid having a glycerol phosphate ester at sn-1 position rather than sn-3 and has one acyl group attached to each of the glycerol moieties. The acyl groups of BMP is rich in polyunsaturated species.

Biochem/physiol Actions

BMP (bis(monoacylglycerol)phosphate) (BMP) is found in the retinal pigment epithelium of healthy human retina. BMP lipids regulates cholesterol level in endosomes. It is implicated in endosomal/lysosomal storage diseases like Niemann-Pick and neuronal ceroid lipofuscinosis diseases. BMP22/4PBPA is a small molecule inhibitor of autotaxin (ATX). 4PBPA has relatively a longer half-life and also reduces the lysophosphatidic acid concentration in plasma. BMP22 is implicated in reducing the bone erosion and systemic bone loss.

Packaging

5ML Glass Amber Screw Cap Vial (870865P-1MG)
5ML Glass Amber Screw Cap Vial (870865P-5MG)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Visite la Librería de documentos

Transacylase formation of bis (monoacylglycerol) phosphate
Heravi J and Waite M
Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, 1437(3), 277-286 (1999)
Osteoclast-derived Autotaxin, a distinguishing factor for inflammatory bone loss
Flammier S, et al.
Arthritis and Rheumatism (2019)
Controlling cancer through the autotaxin-lysophosphatidic acid receptor axis
Gotoh M, et al.
Biochemical Society Transactions, 40(1), 31-36 (2012)
Bis (monoacylglycero) phosphate lipids in the retinal pigment epithelium implicate lysosomal/endosomal dysfunction in a model of Stargardt disease and human retinas
Anderson DMG, et al.
Scientific Reports, 7(1), 17352-17352 (2017)

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