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860536P

Avanti

Sphinganine-1-Phosphate (d18:0)

Avanti Research™ - A Croda Brand 860536P, powder

Sinónimos:

D-erythro-sphinganine-1-phosphate

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About This Item

Fórmula empírica (notación de Hill):
C18H40NO5P
Número de CAS:
19794-97-9
Peso molecular:
381.49
UNSPSC Code:
12352211
NACRES:
NA.25

form

powder

packaging

pkg of 1 × 1 mg (860536P-1mg)
pkg of 1 × 5 mg (860536P-5mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand 860536P

lipid type

sphingolipids

shipped in

dry ice

storage temp.

−20°C

SMILES string

[H][C@](CCCCCCCCCCCCCCC)(O)[C@]([NH3+])([H])COP([O-])(O)=O

InChI

1S/C18H40NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h17-18,20H,2-16,19H2,1H3,(H2,21,22,23)/t17-,18+/m0/s1

InChI key

YHEDRJPUIRMZMP-ZWKOTPCHSA-N

Categorías relacionadas

General description

Sphinganine-1-Phosphate (SA1P) is a bioactive lipid present in mammals. It is produced from the sphingoid base, sphinganine in the presence of sphingosine kinase (SPHK).

Application

Sphinganine-1-Phosphate (d18:0) has been used as a reference standard in ultra performance liquid chromatography coupled to a mass spectrometry. It is suitable for use as an internal standard for ultra high performance liquid chromatography for the quantification of blood and muscle sphingolipid. Sphinganine-1-phosphate (d18:0) is also suitable for use as standard in liquid chromatography tandem mass spectrometry.

Biochem/physiol Actions

Sphinganine-1-Phosphate (SA1P) is an important marker for cancer and immune system disorders studies. It elicits protective functionality in hepatic ischemia. Elevated levels of SA1P is observed in hepatocellular carcinoma.

Packaging

5 mL Amber Glass Screw Cap Vial (860536P-1mg)
5 mL Amber Glass Screw Cap Vial (860536P-5mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

also commonly purchased with this product

Referencia del producto
Descripción
Precios

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Serum sphingolipidomic analyses reveal an upregulation of C16-ceramide and sphingosine-1-phosphate in hepatocellular carcinoma
Grammatikos G, et al.
Testing, 7(14), 18095-18095 (2016)
Accurate quantification of sphingosine-1-phosphate in normal and Fabry disease plasma, cells and tissues by LC-MS/MS with 13C-encoded natural S1P as internal standard
Mirzaian M, et al.
Clinica Chimica Acta; International Journal of Clinical Chemistry, 459(5), 36-44 (2016)
Exercise increases sphingoid base-1-phosphate levels in human blood and skeletal muscle in a time-and intensity-dependent manner
Baranowski M, et al.
European Journal of Applied Physiology, 115(5), 993-1003 (2015)
Metabolomic insights into system-wide coordination of vertebrate metamorphosis
Ichu T, et al.
BMC Developmental Biology, 14(1), 5-5 (2014)
Katja Jakobi et al.
International journal of molecular sciences, 21(7) (2020-04-05)
Hepatocellular carcinoma (HCC) shows a remarkable heterogeneity and is recognized as a chemoresistant tumor with dismal prognosis. In previous studies, we observed significant alterations in the serum sphingolipids of patients with HCC. This study aimed to investigate the in vitro

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