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850336P

Avanti

MAPCHO™-12

Avanti Research™ - A Croda Brand

Sinónimos:

DPC; Fos-Choline-12; FOS12; FC-12

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About This Item

Fórmula empírica (notación de Hill):
C17H38NO4P
Número de CAS:
29557-51-5
Peso molecular:
351.46
UNSPSC Code:
12352211
NACRES:
NA.25

description

n-dodecylphosphocholine

assay

>99% (TLC)

form

powder

packaging

pkg of 1 × 1 g (850336P-1g)
pkg of 1 × 25 g (850336P-25g)
pkg of 1 × 5 g (850336P-5g)

manufacturer/tradename

Avanti Research™ - A Croda Brand

shipped in

dry ice

storage temp.

−20°C

InChI

1S/C17H38NO4P/c1-5-6-7-8-9-10-11-12-13-14-16-21-23(19,20)22-17-15-18(2,3)4/h5-17H2,1-4H3

InChI key

QBHFVMDLPTZDOI-UHFFFAOYSA-N

Categorías relacionadas

General description

Dodecylphosphocholine is a structural analog of lauroyl lysophosphatidylcholine that is more stable to hydrolytic degradation. The lipid is often used as a detergent for membrane protein solubilization and purification.Dodecylphosphocholine has been shown to improve paracellular permeability of hydrophilic compounds by modulating the tight junctions. This may have implications on its use for oral or nasal drug delivery.
MAPCHO™-12 or n-dodecylphosphocholine is a detergent with short chain.

application

MAPCHO™-12 is suitable for use as detergent for B. subtilis cytochrome b558 protein for nuclear magnetic resonance experiments. It is also suitable for use in the purification of cytoplasmic tail of gp41 (gp41CT) protein and micelle preparation.

Biochem/physiol Actions

MAPCHO™-12 or n-dodecylphosphocholine in combination with 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC) is used for membrane-mimetic bicelle system for orientation based studies in membrane proteins. It provides a zwitterionic surface in the membrane micelle structure.

Packaging

125 mL Amber Wide Mouth Glass Bottle with Screw Cap (850336P-5g)
20 mL Clear Glass Screw Cap Vial (850336P-1g)
250 mL Amber Wide Mouth Glass Bottle with Screw Cap (850336P-25g)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC
MAPCHO is a trademark of Avanti Polar Lipids, LLC

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Nina Liu et al.
Heliyon, 5(12), e03018-e03018 (2020-01-01)
Fusion of host and viral membranes is a crucial step during infection by enveloped viruses. In the structurally-defined "class I″ viral glycoproteins, the formation of a highly stable α-helical bundle by the ectodomain of the fusion subunit (e.g., GP2 for
Solution structure and membrane interaction of the cytoplasmic tail of HIV-1 gp41 protein
Murphy RE, et al.
Structure, 25(11), 1708-1718 (2017)
Magnetically oriented dodecylphosphocholine bicelles for solid-state NMR structure analysis
Nolandt OV, et al.
Biochimica et Biophysica Acta - Biomembranes, 1818(5), 1142-1147 (2012)
Thermodynamics, size, and dynamics of zwitterionic dodecylphosphocholine and anionic sodium dodecyl sulfate mixed micelles
Sikorska E, et al.
Journal of Thermal Analysis and Calorimetry, 123(1), 511-523 (2016)
Roman Brunecky et al.
Biochemistry, 44(49), 16064-16071 (2005-12-08)
A growing number of modules including FYVE domains target key signaling proteins to membranes through specific recognition of lipid headgroups and hydrophobic insertion into bilayers. Despite the critical role of membrane insertion in the function of these modules, the structural
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