850315P
Avanti
08:0 PC
1,2-dioctanoyl-sn-glycero-3-phosphocholine, powder
Sinónimos:
PC(8:0/8:0)
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About This Item
Fórmula empírica (notación de Hill):
C24H48NO8P
Número de CAS:
Peso molecular:
509.61
UNSPSC Code:
51191904
NACRES:
NA.25
Productos recomendados
assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 200 mg (850315P-200mg)
pkg of 1 × 25 mg (850315P-25mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand 850315P
lipid type
phospholipids
cardiolipins
shipped in
dry ice
storage temp.
−20°C
SMILES string
[O-]P(OCC[N+](C)(C)C)(OC[C@]([H])(OC(CCCCCCC)=O)COC(CCCCCCC)=O)=O
Categorías relacionadas
General description
Phosphatidylcholine (PC) is one of the most important constituent of the mucosal layer of the colon. 08:0 PC (1,2-dioctanoyl-sn-glycero-3-phosphocholine/C8PC) is a water soluble short alkyl chain lipid.
The list of Phosphatidylcholine products offered by Avanti is designed to provide compounds having a variety of physical properties. Products available include short chain (C3-C8 are water soluble and hygroscopic), saturated, multi-unsaturated and mixed acid PC′s. All of the products are purified by HPLC, and special precautions are taken to protect the products for oxidization and hydrolysis.
Application
08:0 PC (1,2-dioctanoyl-sn-glycero-3-phosphocholine/C8PC) has been used as a substrate to study the analytical capabilities of several methods to determine water soluble phospholipids containing choline (wCh-PL) and also to study the behavior of the its analytical signal in a synthetic serum matrix (data-Trol). It may also be used as a bicellar model to study their phase behavior and to form a lipid film to study its effect on P-glycoprotein′s (P-gp′s) activity/to compare its effect with TWEEN®80 and Cremophor®EL.
Biochem/physiol Actions
Phosphatidylcholine (PC) can form a hydrophobic surface in the mucus by acting as a surfactant to inhibit the penetrance of bacteria.
Packaging
20 mL Clear Glass Screw Cap Vial (850315P-200mg)
5 mL Clear Glass Sealed Ampule (850315P-25mg)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
Cremophor is a registered trademark of BASF SE
TWEEN is a registered trademark of Croda International PLC
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificados de análisis (COA)
Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»
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Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.
Manuel Weinheimer et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 108, 13-22 (2016-09-04)
The efflux transporter P-glycoprotein (P-gp) significantly modulates drug transport across the intestinal mucosa, strongly reducing the systemic absorption of various active pharmaceutical ingredients. P-gp inhibitors could serve as helpful tools to enhance the oral bioavailability of those substances. As a
Isabel Sanz-Vicente et al.
Analytical biochemistry, 519, 30-37 (2016-12-14)
In this paper we present methods to determine water soluble phospholipids containing choline (wCh-PL). The analytes were hydrolyzed by the enzyme phospholipase D and the choline formed was oxidized by the enzyme Choline Oxidase (ChOx); the fluorescence changes of the
Inflammatory Bowel Disease
Integrative Medicine, 501-516 null
Phase behavior of a binary lipid system containing long- and short-chain phosphatidylcholines
Sun HY, et al.
Royal Society of Chemistry Advances, 7(10), 5715-5724 null
Teruhiko Baba et al.
Chemistry and physics of lipids, 227, 104870-104870 (2020-01-10)
Interfacial properties and membrane protein solubilization activity of a series of partially fluorinated octyl-phosphocholine (PC) surfactants were investigated from the viewpoint of the fluorination degree of the hydrophobic chain. The critical micelle concentration (CMC), surface tension lowering activity, molecular occupied
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