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MilliporeSigma

841118C

Avanti

Egg Trans PE

L-α-phosphatidylethanolamine, transphosphatidylated (Egg, Chicken), chloroform

Sinónimos:

L-a-Phosphatidylethanolamine Transphosphatidylated (prepared from Egg PC)

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About This Item

Número de CAS:
Número MDL:
Código UNSPSC:
12352211
NACRES:
NA.25

Ensayo

>99% (TLC)

Formulario

liquid

envase

pkg of 1 × 2.5 mL (841118C-25mg)

fabricante / nombre comercial

Avanti Research - A Croda Brand 841118C

concentración

10 mg/mL (841118C-25mg)

tipo de lípido

phosphoglycerides

Condiciones de envío

dry ice

temp. de almacenamiento

−20°C

cadena SMILES

[H][C@@](COP([O-])(OCC[NH3+])=O)(OC(CCCCCCC/C=C\CCCCCCCC)=O)COC(CCCCCCCCCCCCCCC)=O

InChI

1S/C39H76NO8P/c1-3-5-7-9-11-13-15-17-18-20-22-24-26-28-30-32-39(42)48-37(36-47-49(43,44)46-34-33-40)35-45-38(41)31-29-27-25-23-21-19-16-14-12-10-8-6-4-2/h17-18,37H,3-16,19-36,40H2,1-2H3,(H,43,44)/b18-17-/t37-/m1/s1

Clave InChI

FHQVHHIBKUMWTI-OTMQOFQLSA-N

Descripción general

Phosphatidylethanolamine (PE) is a phospholipid found in all living organism.[1] The egg yolk contains high levels of unsaturated PE which accounts to 83.10%.[2] The phosphatidylethanolamine (PE) headgroup is a zwitterion, with a negatively charged phosphate group and positively charged free amine group.[3]

Aplicación

Egg Trans PE is suitable for use:
  • in the incubation of platelets for phospholipid enrichment and quantification by ultraperformance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS)[4]
  • in the synthesis of isoketals-phosphatidylethanolamine (IsoK-PE)[5]
  • in the preparation of phospholipid vesicles for factor X activation studies[6]

Acciones bioquímicas o fisiológicas

Phosphatidylethanolamine (PE) along with other phospholipids forms the backbone of biological membranes. PE is known to regulate autophagy. The autophagic membranes possesses PE with high degree of unsaturation.[1] Egg yolk PE has high radical scavenging activity owing to antioxidant potential.[2]

Envase

5 mL Clear Glass Sealed Ampule (841118C-25mg)

Información legal

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Pictogramas

Skull and crossbonesHealth hazard

Palabra de señalización

Danger

Clasificaciones de peligro

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3

Órganos de actuación

Central nervous system, Liver,Kidney

Clase de riesgo para el agua (WGK)

WGK 3


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Isoketals form cytotoxic phosphatidylethanolamine adducts in cells
Sullivan CB, et al.
Journal of Lipid Research, 51(5), 999-1009 (2010)
C Blake Sullivan et al.
Journal of lipid research, 51(5), 999-1009 (2009-12-08)
Levuglandins and their stereo- and regio-isomers (termed isolevuglandins or isoketals) are gamma-ketoaldehydes (IsoK) that rapidly react with lysines to form stable protein adducts. IsoK protein adduct levels increase in several pathological conditions including cardiovascular disease. IsoKs can induce ion channel
Factor VIII C1 domain spikes 2092-2093 and 2158-2159 comprise regions that modulate cofactor function and cellular uptake
Bloem E, et al.
Journal of biological and chemical chronicles, 288(41), 29670-29679 (2013)
Analytical characterization of the role of phospholipids in platelet adhesion and secretion
Koseoglu S, et al.
Analytical Chemistry, 87(1), 413-421 (2014)
The
The Membranes of Cells, 22(3) (2016)

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