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810154P

Avanti

16:0-12:0 NBD PE

Avanti Research™ - A Croda Brand 810154P, powder

Sinónimos:

1-palmitoyl-2-{12-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino]dodecanoyl}-sn-glycero-3-phosphoethanolamine

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About This Item

Fórmula empírica (notación de Hill):
C39H68N5O11P
Número de CAS:
328946-26-5
Peso molecular:
813.96
Número MDL:
MFCD22570234
Código UNSPSC:
12352211
NACRES:
NA.25

Ensayo

>99% (TLC)

Formulario

powder

envase

pkg of 1 × 1 mg (810154P-1mg)
pkg of 5 × 1 mg (810154P-5mg)

fabricante / nombre comercial

Avanti Research™ - A Croda Brand 810154P

Condiciones de envío

dry ice

temp. de almacenamiento

−20°C

Descripción general

N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl) phosphoethanolamine (NBD PE) is a fluorescent probe localized at the membrane interface.[1][2] It possess fluorescent NBD label attached to the headgroup of phosphatidylethanolamine (PE).[2] PE is the parent compound for phosphatidylcholine and phosphatidylethanolamine synthesis[3] and is mostly enriched in brain.[4]

Aplicación

16:0-12:0 NBD PE has been used in lipid extraction assay and in vitro phospholipid fluorescence resonance energy transfer (FRET) assays.[5] It is suitable for the determination of enzyme substrate specificity of lipoteichoic acid synthase (LtaS).[6][7][6]

Acciones bioquímicas o fisiológicas

Phosphoethanolamine (PE) plays a vital role in the prevention of tumor proliferation.[3] N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl) phosphoethanolamine (NBD PE) monitors the Red edge excitation shift (REES) phenomenon with the unique motional and dielectric properties it possesses.[1]

Envase

5 mL Amber Glass Screw Cap Vial (810154P-1mg)
5 mL Amber Glass Screw Cap Vial (810154P-5mg)

Información legal

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Código de clase de almacenamiento

11 - Combustible Solids

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Theoretical Study of Phosphoethanolamine: A Synthetic Anticancer Agent with Broad Antitumor Activity
Lorenzo VP, et al.
Journal of Chemistry, 2016 (2016)
Application of NBD-labeled lipids in membrane and cell biology
Fluorescent methods to study biological membranes, 37-50 (2012)
Ouma Onguka et al.
The Journal of biological chemistry, 290(20), 12744-12752 (2015-04-02)
Phosphatidylethanolamine (PE) is a major cellular phospholipid that can be made by four separate pathways, one of which resides in the mitochondrion. The mitochondrial enzyme that generates PE is phosphatidylserine decarboxylase 1 (Psd1p). The pool of PE produced by Psd1p
María Isabel Hernández-Alvarez et al.
Cell, 177(4), 881-895 (2019-05-06)
Non-alcoholic fatty liver is the most common liver disease worldwide. Here, we show that the mitochondrial protein mitofusin 2 (Mfn2) protects against liver disease. Reduced Mfn2 expression was detected in liver biopsies from patients with non-alcoholic steatohepatitis (NASH). Moreover, reduced Mfn2
Jean E Vance et al.
Biochimica et biophysica acta, 1831(3), 543-554 (2012-09-11)
Phosphatidylserine (PS) and phosphatidylethanolamine (PE) are metabolically related membrane aminophospholipids. In mammalian cells, PS is required for targeting and function of several intracellular signaling proteins. Moreover, PS is asymmetrically distributed in the plasma membrane. Although PS is highly enriched in
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