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141101C

Avanti

Brain Extract Polar

Avanti Research™ - A Croda Brand

Sinónimos:

Brain Polar Lipid Extract (Porcine)

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About This Item

Número de CAS:
86088-88-2
Número MDL:
MFCD18427707
Código UNSPSC:
12352211
NACRES:
NA.25

Formulario

chloroform solution

envase

pkg of 1 × 4 mL (141101C-100mg)
pkg of 5 × 4 mL (141101C-500mg)

fabricante / nombre comercial

Avanti Research™ - A Croda Brand

concentración

25 mg/mL (141101C-100mg)
25 mg/mL (141101C-500mg)

tipo de lípido

lipid extracts

Condiciones de envío

dry ice

temp. de almacenamiento

−20°C

Descripción general

Brain Extract Polar comprises phosphatidylethanolamine as major lipid component. It also contains phosphatidylserine and phosphatidylcholine. The minor components include the phosphatidic acid and phosphatidylinositol.
Brain Polar Lipid Extract is derived from the total lipid extract by precipitation with acetone followed by extraction of the acetone insoluble material with diethyl ether.

Aplicación

Brain Extract Polar has been used as an artificial membrane solution component for permeability studies.[1] It may be used for coating donor plate during parallel artificial membrane permeability assay (PAMPA) to study blood-brain barrier penetration.[2] It may be used in liposome preparation for dynamin self-assembly assay.[3]

Acciones bioquímicas o fisiológicas

Brain lipid, especially the polar fraction plays a key role in the inhibition of prion seeded amyloid formation.[4] Lipid extracts from the mammalian tissues like brain, kidney and liver are used in generating model membranes for mimicking real membranes.[5]

Envase

5 mL Clear Glass Sealed Ampule (141101C-100mg)
5 mL Clear Glass Sealed Ampule (141101C-500mg)

Información legal

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Pictogramas

Skull and crossbonesHealth hazard
GHS06,GHS08

Palabra de señalización

Danger

Clasificaciones de peligro

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3

Órganos de actuación

Central nervous system, Liver,Kidney

Código de clase de almacenamiento

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

does not flash

Punto de inflamabilidad (°C)

does not flash

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Certificados de análisis (COA)

Lot/Batch Number

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Prediction of blood-brain barrier permeation of alpha-adrenergic and imidazoline receptor ligands using PAMPA technique and quantitative-structure permeability relationship analysis
Vucicevic J, et al.
European Journal of Pharmaceutical Sciences, 68(10), 94-105 (2015)
Irene Paterniti et al.
PloS one, 6(1), e15937-e15937 (2011-02-08)
Primary traumatic mechanical injury to the spinal cord (SCI) causes the death of a number of neurons that to date can neither be recovered nor regenerated. During the last years our group has been involved in the design, synthesis and
Laura Campello et al.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 54(1), 142-159 (2020-02-07)
It is well established that oxidative stress and inflammation are common pathogenic features of retinal degenerative diseases. ITH12674 is a novel compound that induces the transcription factor Nrf2; in so doing, the molecule exhibits anti-inflammatory, and antioxidant properties, and affords
Kalirin12 interacts with dynamin
Xin X, et al.
BMC Neuroscience, 10(1), 61-61 (2009)
Chameleon-like behavior of indolylpiperidines in complex with cholinesterases targets: Potent butyrylcholinesterase inhibitors
Chierrito TPC, et al.
European Journal of Medicinal Chemistry, 145(10), 431-444 (2018)
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