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Sigma-Aldrich

Peptide-RGD bioink

suitable for 3D bioprinting applications

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About This Item

UNSPSC Code:
12352201

description

Product components:
Bioink lyophilized powder (100mg)
Preparation solution B (20mL)

form

powder

storage temp.

−20°C

Application

Peptide-RGD bioink is optimized for bioprinting applications and can be printed with great fidelity to create a self-supporting 3D scaffold. This bioink has been designed to work easily and accurately with both extrusion-based and ink-jet printers to produce high-quality and reliable prints. Peptide - RGD bioink is based on self-assembling peptide hydrogel technology. The resulting hydrogel is a nanofibrous network with a similar nanoscale matrix structure to that of the native extracellular matrix (ECM) in human tissue. This bioink prints without the need for temperature or pH adjustment, UV curing, or addition of reactive cross-linking reagents, all of which can be detrimental to the health of cells. The gelation is simply triggered by the addition of cell culture media.

Peptide-RGD bioink is further functionalized with fibronectin (RGD), thereby encouraging better cell-matrix interactions to provide an optimal environment for the culture.

The product is provided as a lyophilized peptide bioink powder and a preparation solution, which allows formulation of gels with different stiffness and rigidity that can emulate specific physical properties of a wide range of different tissue types.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3


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Printable Self-Assembled Peptide Bio-Inks: Promising Future Applications in Nanomedicine
Das A K and Jadhav R G
Archives of Nanomedicine: Open Access Journal, 1(3) (2018)
Yihua Loo et al.
Nano letters, 15(10), 6919-6925 (2015-07-28)
Printable scaffolds with adequate mechanical strength and stiffness are sought after to ensure viability of printed cells and tissues. We report the first peptide bioinks-lysine-containing hexapeptides that self-assemble into stable, nanofibrous three-dimensional hydrogels with unprecedented stiffness of up to 40

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