This product is prepared from a porcine Type A gelatin.
904643
Thiol functionalized gelatin
Sinónimos:
Functionalized gelatin, Gelatin thiol, Gelatin-SH• Gel-SH, SH functionalized gelatin, Thiol functionalized gelatin, Thiol gelatin, Thiolated gelatin
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1 G
$207.00
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1 G
$207.00
About This Item
UNSPSC Code:
12352105
NACRES:
NA.23
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description
NMR: Conforms to structure
Thiol content 150-350 μmol/g
assay
150-350 μmol/g (Free Thiol Concentration by UVVI, UV-vis)
form
powder
color
white to pale yellow
storage temp.
−20°C
Application
Gelatin has received significant attention in the biomedical field due to its inherent bioactivity. Functionalized gelatin can be cross-linked with the formation of covalent bonds into highly crosslinked structures, such as hydrogels. Recent literature suggests that radical-mediated polymerized hydrogels may not be ideal for cell and protein encapsulation due to radical-mediated damage, hindered molecular transport, or altered cell-cell/cell-material interactions. Thiol-modified gelatin can be used to form hydrogels with multifunctional norbornene or allyl crosslinkers via thiol-ene click or Michael-addition reactions.
To improve solubility in water, heat to 40°C and stir for 10-15 minutes.
Caution
Material should be handled under nitrogen - air/oxygen & moisture are to be avoided.
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Los clientes también vieron
Modular Cross-Linking of Gelatin-Based Thiol?Norbornene Hydrogels for in Vitro 3D Culture of Hepatocellular Carcinoma Cells
Greene T, et al
ACS biomaterials science & engineering, 1 (12), 1314?1323-1314?1323 (2015)
Vinh X Truong et al.
Biomacromolecules, 18(3), 757-766 (2017-02-15)
Swelling of hydrogels leads to a decrease in mechanical performance coupled with complications in solute diffusion. In addition, hydrogel swelling affects patient safety in biomedical applications such as compression of tissue and fluid blockage. A conventional strategy for suppressing swelling
Gelatin hydrogels formed by orthogonal thiol?norbornene photochemistry for cell encapsulation
Munoz Z, et al.
Biomaterials Science, 2, 1063-1072 (2014)
Artículos
Professor Shrike Zhang (Harvard Medical School, USA) discusses advances in 3D-bioprinted tissue models for in vitro drug testing, reviews bioink selections, and provides application examples of 3D bioprinting in tissue model biofabrication.
Protocolos
Frequently asked questions (FAQs) for KAPA SYBR® FAST One-Step qRT-PCR Kits.
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Could I ask what gelatin is used for the modification? Is it typ A or type B, and is the origin bovine or porcin?
1 answer-
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What is the expected bloom number for product 904643?
1 answer-
It is bloom 300.
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How should it be dissolved? I tried to make a 50g/L PBS solution and left it in an incubator at 40 degrees overnight, but it did not dissolve.
1 answer-
Heat the gelatin solution to at least 50 °C while stirring continuously. The gelatin should dissolve to form a slightly hazy solution with no particulates. If the issue persists, please navigate to the link https://www.sigmaaldrich.com/techservice, and click on "Product Technical Inquiries" under the Products Section with all the required information so that a member of the Technical Service team can reach out to assist further. Thank you.
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