901568

Bromo-PEG₃-acid

• Fórmula empírica (notación de Hill): C₉H₁₇BrO₅
• Número de CAS: 782475-35-8
• Peso molecular: 285.13
• MDL number: MFCD22574820
• UNSPSC Code: 12352101
• NACRES: NA.22

Propiedades

• form: liquid
• reaction suitability: reagent type: linker
• functional group: bromo; carboxylic acid
• storage temp.: −20°C
• SMILES string: BrCCOCCOCCOCCC(O)=O

Descripción

Application

Bromo-PEG₃-acid is a heterobifunctional, PEGylated crosslinker featuring a bromo group at one end and a carboxyl group at the other. The hydrophillic PEG linker facilitates solubility in biological applications. Bromo-PEG₃-acid can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC^® molecules) for targeted protein degradation.

This is a crosslinker with a bromo group on one end and a carboxyl group on the other end. The compound contains three PEG units to help improve solubility.

Legal Information

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Información de seguridad

• Storage Class: 10 - Combustible liquids
• wgk_germany: WGK 3