778907

(2-Hidroxipropil)-β-ciclodextrina

Produced by Wacker Chemie AG, Burghausen, Germany, Life Science

• Sinónimos: Cavasol^® W7 HP
• Número de CAS: 128446-35-5
• EC Number: 420-920-1
• UNSPSC Code: 12352201
• NACRES: NA.22

Propiedades

• grade: Produced by Wacker Chemie AG, Burghausen, Germany, Life Science
• form: powder
• extent of labeling: 0.59-0.73 molar substitution
• impurities: ≤0.1% related substances, any (Ph Eur); ≤0.5% propylene glycol (Ph Eur); ≤1.0% β-dex (Ph Eur); ≤1.0% related substances, total other; ≤1.0 ppm propylene oxide
• loss: ≤10.0% loss on drying
• conductivity: ≤200 μS/cm (Ph Eur)
• suitability: clear, colorless for appearance of solution; positive for identity
• SMILES string: CC(O)COCC1OC2OC3C(COCC(C)O)OC(OC4C(COCC(C)O)OC(OC5C(COCC(C)O)OC(OC6C(COCC(C)O)OC(OC7C(COCC(C)O)OC(OC8C(COCC(C)O)OC(OC1C(OCC(C)O)C2OCC(C)O)C(OCC(C)O)C8OCC(C)O)C(OCC(C)O)C7OCC(C)O)C(OCC(C)O)C6OCC(C)O)C(OCC(C)O)C5OCC(C)O)C(OCC(C)O)C4OCC(C)O)C(OCC(C)O)C3OCC(C)O
• InChI: 1S/C63H112O42/c1-22(64)8-85-15-29-50-36(71)43(78)57(92-29)100-51-30(16-86-9-23(2)65)94-59(45(80)38(51)73)102-53-32(18-88-11-25(4)67)96-61(47(82)40(53)75)104-55-34(20-90-13-27(6)69)98-63(49(84)42(55)77)105-56-35(21-91-14-28(7)70)97-62(48(83)41(56)76)103-54-33(19-89-12-26(5)68)95-60(46(81)39(54)74)101-52-31(17-87-10-24(3)66)93-58(99-50)44(79)37(52)72/h22-84H,8-21H2,1-7H3/t22?,23?,24?,25?,26?,27?,28?,29-,30-,31?,32?,33?,34?,35?,36?,37-,38?,39-,40+,41+,42+,43?,44+,45?,46+,47+,48+,49+,50+,51+,52-,53-,54-,55-,56-,57+,58-,59+,60-,61-,62-,63-/m1/s1
• InChI key: ODLHGICHYURWBS-RYJYQAAZSA-N

Descripción

Application

(2-Hydroxypropyl)-β-cyclodextrin can be used:

• In the preparation of imidazole nucleosides via enzymatic transglycosylation to improve the solubility and/or stability of 4-aryl and 4-heteroaryl-1H-imidazole reactants.
• Cyanazine-hydroxypropyl-β-cyclodextrin inclusion complex with enhanced water solubility when compared to cyanazine.

La solubilidad de los fármacos lipófilos aumenta linealmente con la concentración de hidroxipropil-β-ciclodextrina (HBC) en disolución acuosa debido al complejo entre la HBC y el fármaco. Este complejo tipo huésped-anfitrión se forma entre el fármaco y la cavidad no polar de la HBC que tiene como consecuencia una mayor solubilidad. Las disoluciones pueden liofilizarse para producir polvos libremente solubles. No tóxico en conejos ni ratones.

Legal Information

Cavasol is a registered trademark of Wacker Chemie AG

Información de seguridad

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable