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764752

Sigma-Aldrich

Poly(ethylene glycol) methyl ether-block-poly(lactide-co-glycolide)

PEG average Mn 5,000, PLGA Mn 55,000

Sinónimos:

PEG-PLGA, Polyethylene glycol, mPEG-b-PLGA, mPEG-b-PLGA

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1 G
$319.00

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About This Item

Fórmula lineal:
H[(C3H4O2)x(C2H2O2)y]mO[C2H4O]nCH3
Código UNSPSC:
12162002
NACRES:
NA.23

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descripción

typical PEG PDI < 1.1; overall PDI < 2.5

Formulario

pellets

cociente alimentación

lactide:glycolide 50:50

mol peso

PEG average Mn 5,000
PLGA Mn 55,000
average Mn 60,000 (total)

marco temporal de la degradación

1-4 weeks

temperatura de transición

Tg 10 °C(lit.)
Tm 254-259 °C

PDI

<1.2

temp. de almacenamiento

2-8°C

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Descripción general

Amphiphilic block copolymers (AmBC) are made up of two chemically different homopolymer blocks. One of the block is hydrophilic and the other one is hydrophobic. These macromolecules have the properties to self-assemble when dissolved in an aqueous media. PEG-PLGA is one the most commonly used biodegradable amphiphilic block copolymers for drug delivery applications. PEG is the hydrophilic part and PLGA is the hydrophobic part.[1]

Aplicación

Used in the synthesis of targeted nanoparticles which are used for differential delivery and controlled release of drugs.[2][3]

Características y beneficios

  • Good biocompatibility, low immunogenicity and good degradability.
  • Properties can be easily modulated by changing the block copolymer segment sizes to suit a particular application.[1]

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

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Certificados de análisis (COA)

Lot/Batch Number
MKCP0963
MKCL3523
MKCJ1921
MKCG4765
MKCD1162

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Hunter Bachman et al.
Lab on a chip, 20(7), 1238-1248 (2020-02-28)
Whether reagents and samples need to be combined to achieve a desired reaction, or precise concentrations of solutions need to be mixed and delivered downstream, thorough mixing remains a critical step in many microfluidics-based biological and chemical assays and analyses.
Thermosensitive self-assembling block copolymers as drug delivery systems
Bonacucina, G., Cespi, M., Mencarelli, G., Giorgioni, G., &amp; Palmieri, G. F.
Polymers (Basel, Switzerland), 3(2), 779-811 (2011)
Frank Gu et al.
Proceedings of the National Academy of Sciences of the United States of America, 105(7), 2586-2591 (2008-02-15)
There has been progressively heightened interest in the development of targeted nanoparticles (NPs) for differential delivery and controlled release of drugs. Despite nearly three decades of research, approaches to reproducibly formulate targeted NPs with the optimal biophysicochemical properties have remained
Sara Moufarrij et al.
Scientific reports, 10(1), 3470-3470 (2020-02-28)
Novel therapies are urgently needed for ovarian cancer, the deadliest gynecologic malignancy. Ovarian cancer has thus far been refractory to immunotherapies that stimulate the host immune system to recognize and kill cancer cells. This may be because of a suppressive
PLGA-PEG Encapsulated sitamaquine nanoparticles drug delivery system against Leishmania donovani
Kumara, R., Sahoo, G. C., Pandeya, K., Dasa, V. N. R., Yousuf, M., Ansaria, S. R., &amp; Dasa, P.
Journal of Scientific and Innovative Research, 3(1), 85-90 (2014)

Artículos

Solubility Enhancement of Hydrophobic Drugs

Micelle formation addresses low solubility in IV drug delivery, overcoming clinical limitations.

Electrospun Nanofibers for Drug Delivery Systems

Local delivery of bioactive molecules using an implantable device can decrease the amount of drug dose required as well as non-target site toxicities compared to oral or systemic drug administration.

Polymersomes for Drug Delivery

The development of drugs that target specific locations within the human body remains one of the greatest challenges in biomedicine today.

Biodegradable Polyester Nanoparticle Formation

AliAliphatic polyesters, including polylactide and polyglycolide, are biodegradable polymers widely used in medical applications.

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