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MilliporeSigma

764590

Sigma-Aldrich

Poly(L-lactide)

average Mn 5,000, PDI ≤1.2

Sinónimos:

PLLA, Polylactide, L-Lactide polymer, PLA, Poly(L-Lactic acid)

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About This Item

Fórmula lineal:
H(C3H4O2)nOCH3
UNSPSC Code:
12162002
NACRES:
NA.23

form

solid

optical activity

[α]22/D -147°, c = 0.5% in chloroform

mol wt

average Mn 5,000

degradation timeframe

>3 years

transition temp

Tm 149-154 °C

PDI

≤1.2

storage temp.

2-8°C

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General description

Poly (L-lactide) is a semi-crystalline polymer which exhibits strong optical rotation and good mechanical properties. It is mostly used in the synthesis of degradable polymers which are used in orthopaedic devices, in dental applications, as scaffolds for autografted new skin, wound covers, anastomose systems and stents. They are biodegradable since the polyester backbone degrades by simple hydrolysis to form non-toxic compounds.

Application

Drug Delivery including coating nanoparticles;end-group functionalization ;macroinitiator or block precursor.

Features and Benefits

High initial strength, good strength retention and high amount of crystallinity as much as 70% which in turn is responsible for the very slow degradation rate.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


Certificados de análisis (COA)

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Synthesis and thermal properties of novel star-shaped poly (l-lactide)s with starburst PAMAM-OH dendrimer macroinitiator.
Zhao, Y. L., Cai, Q., Jiang, J., Shuai, X. T., Bei, J. Z., Chen, C. F., & Xi, F.
Polymer, 43(22), 5819-5825 (2002)
Chemical synthesis of polylactide and its copolymers for medical applications
Bendix, D.
Polymer Degradation and Stability, 59(1), 129-135 (1998)
Effect of poly (ethylene glycol)-block- poly (L-lactide) on the poly [(R)-3-hydroxybutyrate]/poly (L-lactide) blends
Yoon, J. S., Lee, W. S., Kim, K. S., Chin, I. J., Kim, M. N., & Kim, C.
Eur. Polymer J., 36(2), 435-442 (2000)
Wolf, Florian F.; et al.
Macromolecules, 42, 5622-5628 (2009)
Zhang, Wen-Bin; et al.
Macromolecules, 44, 2589-2596 (2011)

Artículos

Professor Aran discusses engineering graphene-based materials through careful functionalization, enabling diverse applications.

Local delivery of bioactive molecules using an implantable device can decrease the amount of drug dose required as well as non-target site toxicities compared to oral or systemic drug administration.

Synthetic aliphatic polyesters dominate resorbable biomaterials in clinical use.

AliAliphatic polyesters, including polylactide and polyglycolide, are biodegradable polymers widely used in medical applications.

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