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Documentos

480959

Sigma-Aldrich

Glycolamide

98%

Sinónimos:

2-Hydroxyacetamide

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About This Item

Fórmula lineal:
HOCH2CONH2
Número de CAS:
598-42-5
Peso molecular:
75.07
MDL number:
MFCD00047895
UNSPSC Code:
12352100
PubChem Substance ID:
24871727
NACRES:
NA.22

assay

98%

mp

118-120 °C (lit.)

SMILES string

NC(=O)CO

InChI

1S/C2H5NO2/c3-2(5)1-4/h4H,1H2,(H2,3,5)

InChI key

TZGPACAKMCUCKX-UHFFFAOYSA-N

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General description

Glycolamide, an isomer of glycine, can be synthesized by the ammonolysis of ethyl glycolate. The conformational analysis of glycolamide has been reported. Its diffusion coefficient in water and partial molal isothermal compressibility has been determined. Its thermodynamic properties have been investigated. Its osmotic and activity coefficients have been obtained.

Application

Glycolamide may be used in the preparation of phosphoglycolamide.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Sigma-Aldrich

E9508

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Fereidoon Daryaee et al.
European journal of medicinal chemistry, 44(1), 289-295 (2008-04-26)
On the basis of the structural similarity of N-substituted glycolamides with N-glycolyl muramic acid residues of the cell wall of Mycobacterium tuberculosis, a series of these compounds were designed and synthesized by the reaction of glycolic acid acetonide 1 (2,2-dimethyl-5-oxo-1,3-dioxolane)
Parmeshwari K Halen et al.
Mini reviews in medicinal chemistry, 9(1), 124-139 (2009-01-20)
Non-steroidal anti-inflammatory drugs (NSAIDs), commonly used for the treatment of chronic inflammatory diseases suffer from several undesired side effects, the most important being gastrointestinal (GI) irritation and ulceration. The prodrug designing is one of the several strategies used to overcome
A K Bansal et al.
Drug development and industrial pharmacy, 27(1), 63-70 (2001-03-15)
Glycolamide esters of ibuprofen (I), namely, unsubstituted (II), N,N dimethyl (III), and N,N diethyl (IV), were synthesized and studied for different physicochemical, pharmacological, and toxicological properties. They were comparable with I in respect of anti-inflammatory and analgesic activity but did
P R Brown et al.
Journal of general microbiology, 133(6), 1527-1533 (1987-06-01)
A positive selection is described for isolating amidase-negative mutants from Pseudomonas aeruginosa strains. The method is based on the conversion, via amidase activity, of glycollamide to glycollate which is growth inhibitory. Three types of mutant were isolated on lactate medium
Partial molal isothermal compressibility of glycine, DL-α-alanine, glycylglycine, glycolamide, and lactamide.
Yayanos AA.
The Journal of Physical Chemistry, 97(49), 13027-13028 (1993)
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