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430471

Sigma-Aldrich

Poly(D,L-lactide-co-glycolide)

ester terminated, Mw 50,000-75,000

Sinónimos:

Lactel® B6006-1, PLGA

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1 G
$82.40
5 G
$284.00

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1 G
$82.40
5 G
$284.00

About This Item

Fórmula lineal:
[C3H4O2]x[C2H2O2]y
Número MDL:
MFCD00131930
Código UNSPSC:
12162002
ID de la sustancia en PubChem:
24866924
NACRES:
NA.23

$82.40

Disponible para envío el07 de abril de 2025Detalles

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Formulario

amorphous

cociente alimentación

lactide:glycolide 85:15

mol peso

Mw 50,000-75,000

marco temporal de la degradación

<6 months

viscosidad

0.55-0.75 dL/g, 0.1 % (w/v) in chloroform(25 °C)

temperatura de transición

Tg 45-50 °C

solubilidad

ethyl acetate, chloroform, acetone and THF: soluble

temp. de almacenamiento

2-8°C

cadena SMILES

OCC(O)=O.CC(O)C(O)=O

InChI

1S/C3H6O3.C2H4O3/c1-2(4)3(5)6;3-1-2(4)5/h2,4H,1H3,(H,5,6);3H,1H2,(H,4,5)

Clave InChI

XBBVURRQGJPTHH-UHFFFAOYSA-N

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Descripción general

Characteristic properties of ester terminated poly(D,L-lactide-co-glycolide) (PLGA) are in vivo biodegradability, tunable drug release profile and very high encapsulation capacity.[1]

Aplicación

PLGA polymers find uses in the production of biodegradable medical sutures and for controlled drug release. PLGA microspheres have been reported for use in controlled release of human growth hormone.[1] Thin membranes of blended polymers constituting of PLGA/polycaprolactone/β-tricalcium phosphate have been used in guided bone regeneration.[2]

Características y beneficios

Controlled release of bioactive agents, sutures and bioabsorbable implantable devices.

Forma física

Biocompatible, biodegradable polymer.

Información legal

Lactel is a registered trademark of Evonik Corp

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Equipo de protección personal

Eyeshields, Gloves, type N95 (US)

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Certificados de análisis (COA)

Lot/Batch Number
MKCW9918
MKCW1331
MKCT1966
MKCH4706
MKCM6080

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Fabrication of blended polycaprolactone/poly (lactic-co-glycolic acid)/?-tricalcium phosphate thin membrane using solid freeform fabrication technology for guided bone regeneration
Shim JH, et al.
Tissue Engineering: Part A, 19(3-4), 317-328 null
Preparation and characterization of poly (D, L-lactide-co-glycolide) microspheres for controlled release of human growth hormone
Capan Y, et al.
Aaps Pharmscitech, 4(2), 147-156 (2003)
Manjae Gil et al.
Advanced science (Weinheim, Baden-Wurttemberg, Germany), 5(6), 1800024-1800024 (2018-06-26)
Anisotropically compartmentalized microparticles have attracted increasing interest in areas ranging from sensing, drug delivery, and catalysis to microactuators. Herein, a facile method is reported for the preparation of helically decorated microbuilding blocks, using a modified electrohydrodynamic cojetting method. Bicompartmental microfibers
Ayelen L Helling et al.
Tissue engineering. Part A, 25(3-4), 214-223 (2018-10-04)
In human skin the junction between the epidermis and dermis undulates. Epidermal stem cells pattern according to their position relative to those undulations. Here we describe a rig in which epidermal cells are cultured on a collagen-coated poly(d,l-lactide-co-glycolide) (PLGA) membrane.
Teresa Musumeci et al.
International journal of pharmaceutics, 440(2), 135-140 (2012-10-20)
Melatonin, a neurohormone secreted by the pineal gland, is able to modulate intraocular pressure (IOP). The aim of this study was to generate nanoparticle (NPs) sustained release formulations that allow to extend the pre-corneal residence time of melatonin, thus prolonging
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Biodegradable Polyester Nanoparticle Formation

AliAliphatic polyesters, including polylactide and polyglycolide, are biodegradable polymers widely used in medical applications.

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Questions

1–8 of 8 Questions  

  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

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  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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  3. What is the tensile strength of Product No. 403471 Poly(DL-lactide-co-glycolide)?

    1 answer

    1. Product 430471 has a tensile strength of 6000 - 8000 psi, with an elongation of 3-10%.

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  4. Is Product No. 403471 a resorbable polymer?

    1 answer

    1. Yes, Product No. 430471 has a resorption time of 5-6 months.

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  5. What is the density of Product No. 430471 Poly(DL-lactide-co-glycolide)?

    1 answer

    1. According to the manufacturer, product 430471 has a theoretical density of 1.27g/mL.

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  6. What are the end groups of Product No. 430471 (Poly(DL-lactide-co-glycolide)?

    1 answer

    1. Product 430471 has a dodecyl (12 carbon) ester on one end of the polymer chain and a hydroxyl end group on the other.

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  7. How is this Product No. 430471 synthesized (Poly(DL-lactide-co-glycolide)?

    1 answer

    1. To synthesize product 430471, 1-dodecanol is used as an initiator and stannous octoate is used as a catalyst to start the ring opening polymerization of D,L-lactide and glycolide monomers.

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  8. What is the Department of Transportation shipping information for this product?

    1 answer

    1. Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.

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