232890

2′,6′-Difluoroacetophenone

97%

• Fórmula lineal: F₂C₆H₃COCH₃
• Número de CAS: 13670-99-0
• Peso molecular: 156.13
• EC Number: 237-151-9
• MDL number: MFCD00000328
• UNSPSC Code: 12352100
• PubChem Substance ID: 24853937
• NACRES: NA.22

Propiedades

• assay: 97%
• form: liquid
• refractive index: n20/D 1.48 (lit.)
• bp: 76-79 °C/15 mmHg (lit.)
• density: 1.197 g/mL at 25 °C (lit.)
• functional group: fluoro; ketone
• SMILES string: CC(=O)c1c(F)cccc1F
• InChI: 1S/C8H6F2O/c1-5(11)8-6(9)3-2-4-7(8)10/h2-4H,1H3
• InChI key: VGIIILXIQLXVLC-UHFFFAOYSA-N

Descripción

General description

2′,6′-Difluoroacetophenone undergoes ruthenium-catalyzed phenylation with phenylboronate via carbon-fluorine bond cleavage to yield 2′,6′-diphenylacetophenone[1].

Application

2′,6′-Difluoroacetophenone was used in the synthesis of 2-amino-4-alkyl- and 2-amino-4-arylquinazolines[2].

Información de seguridad

• pictograms: GHS07
• signalword: Warning
• hcodes: H315,H319,H335
• pcodes: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• target_organs: Respiratory system
• Storage Class: 10 - Combustible liquids
• wgk_germany: WGK 3
• flash_point_f: 170.6 °F - closed cup
• flash_point_c: 77 °C - closed cup
• ppe: Eyeshields, Gloves, type ABEK (EN14387) respirator filter